127205-22-5

Upstream product

• 127205-16-7 2-amino-6-benzyloxy-7-<2'-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl>-7H-purine 
• 17495-10-2 N²-acetyl-7-benzylguanine 
• 17495-11-3 N²-acetyl-9-benzylguanine 
• 19962-37-9 N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide 
• 127218-58-0 2-(2,2-dimethyl-1,3-dioxan-5-yl)ethyl 4-methylbenzenesulfonate 
• 102147-75-1 2,2-dimethyl-5-(2'-hydroxyethyl)-1,3-dioxane 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 17495-12-4 2-amino-7-benzyl-1H-purin-6(7H)-one 
• 14937-72-5 9-benzylguanine 
• 118-00-3 G 

Relevant academic research and scientific papers

Regioselective functionalization of guanine: Simple and practical synthesis of 7- and 9-alkylated guanines starting from guanosine

Reaction of N2-acetyl-9- and/or -7-benzylated guanines 8 and 12 with selected alkylating agents in 1-methyl-2-pyrrolidone at 120°C yielded the guaninium salts 9 and 13. The salts were consequently transformed by phase transfer hydrogenation into N7- and N9-isomers 10 and 14, respectively, in a highly regioselective manner. A convenient deoxygenation of both derivatives, achieved via the corresponding O6-arenesulfonates, into 2-aminopurine potential prodrugs was also established.

Carba-acyclonucleoside antiherpetic agents

Ganciclovir 2 and 2'-carba-ganciclovir 5a are anti-viral agents differing structurally only in the replacement of an oxygen by a methylene group and yet expressing their biological properties along mechanistically independent pathways. Methoxy, hydroxy an