127222-71-3Relevant academic research and scientific papers
Design and Synthesis of Novel Ibuprofen Derivatives as Selective COX-2 Inhibitors and Potential Anti-Inflammatory Agents: Evaluation of PGE2, TNF-α, IL-6 and Histopathological Study
El-Dash, Yara Sayed,El-Nassan, Hala Bakr,Halim, Peter Amir
, p. 427 - 443 (2022/03/09)
Background: The reported binding mode of ibuprofen in the COX-2 binding site indicat-ed that the carboxylic group binds with Arg-120 and Tyr-355 at the entrance of the cyclooxygenase channel and does not extend into the pocket. This accounted for the non-
Biology-oriented drug synthesis (BIODS), in vitro urease inhibitory activity, and in silico studies on ibuprofen derivatives
Seraj, Faiza,Kanwal,Khan, Khalid Mohammed,Khan, Ajmal,Ali, Muhammad,Khalil, Ruqaiya,Ul-Haq, Zaheer,Hameed, Shehryar,Taha, Muhammad,Salar, Uzma,Perveen, Shahnaz
, p. 143 - 157 (2020/01/28)
Abstract: Novel ibuprofen derivatives 1–19 including ibuprofen hydrazide 1, and substituted thiourea derivatives 2–19 were synthesized and characterized by EI-MS, FAB-MS, HREI-MS, HRFAB-MS, 1H-, and 13C-NMR spectroscopic techniques.
Design, synthesis and antiinflammatory activity of some 1,3,4-oxadiazole derivatives
Omar,Mahfouz,Rahman
, p. 819 - 825 (2007/10/03)
A series of substituted 1,3,4-oxadiazole derivatives 19-34 were synthesized as antiinflammatory agents. The target compounds were obtained by cyclodesulfurization of the corresponding thiosemicarbazides 3-18 using either dicyclohexylcarbodiimide DCC, or I
