41283-72-1Relevant articles and documents
Site-Specific Oxidation of (sp3)C-C(sp3)/H Bonds by NaNO2/HCl
Zhao, Jianyou,Shen, Tong,Sun, Zhihui,Wang, Nengyong,Yang, Le,Wu, Jintao,You, Huichao,Liu, Zhong-Quan
supporting information, p. 4057 - 4061 (2021/05/26)
A site-specific oxidation of (sp3)C-C(sp3) and (sp3)C-H bonds in aryl alkanes by the use of NaNO2/HCl was explored. The method is chemical-oxidant-free, transition-metal-free, uses water as the solvent, and proceeds under mild conditions, making it valuable and attractive to synthetic organic chemistry.
Phenyl substituted thiazole linked 1, 2, 4-triazole derivatives: Synthesis and their biological evaluation
Jain, Sonika,Dhall, Esha,Devi, Meenu,Sharma, Swapnil,Dwivedi, Jaya,Sahu, Sanjeev Kumar
, p. 727 - 734 (2021/09/30)
Synthesize and evaluate some phenyl substituted thiazole linked 1, 2, 4-triazole derivatives as antimicrobial agents. Compounds containing 1, 2, 4-triazole moieties are widely used as antimicrobial and antifungal agents whereas thiazole is another heterocyclic ring exhibiting various pharmacological actions. It is interesting to incorporate different bioactive pharmacophores in the same molecular framework to examine cumulative effect exerted by the moiety. This hypothesis was applied in research work by having triazole and thiazole in the same molecular framework. The present work was mainly focused on synthesis of some 1, 2, 4-triazole derivatives linking with phenyl substituted thiazole nucleus and their evaluation for biological activity. The compounds (8a-8j) were synthesized as per design scheme and elucidated their structures using different spectroscopic data of IR, 1HNMR, 13CNMR & mass spectroscopy. These synthesized derivatives were evaluated for their antibacterial activity using broth dilution assay. Further, mechanism of action of test compounds was examined using protein leakage assay. All the spectral data were confirmed the synthesis of phenyl substituted thiazole linked 1, 2, 4-triazole derivatives and some of them exhibited significant antimicrobial activity. Amongst all compound 8c showed most potent activity with lowest IC50 values 180 μg/ml and 120 μg/ml against S. aureus & amp; B. cereus respectively. Whereas compound 8j demonstrated strong inhibitory activities only against negative strains P. aeruginosa and E. coli with lowest IC50 values 240 μg/mL and 200μg/mL respectively.
Ibuprofen-based chemosensor for efficient binding and sensing of Cu2+ ion in aqueous medium
Hooda, Sunita,Kumar, Pramod,Kumar, Vikrant,Lal, Shyam,Prakash, Kunal
, (2019/09/06)
An ibuprofen based molecular receptor R1 (N-[2-[(2-Hydroxy-benzylidene)-amino]-ethyl]-2-(4-isobutyl-phenyl)-propionamide) was developed for the detection of Cu2+ ion in aqueous medium by absorbance and fluorescence techniques. Binding constants (4.89–5.67 × 103 M?1) and detection limits (1.71–2.12 μM) showed significant sensing ability. SEM and PXRD techniques were employed to establish the complex formation between R1 and Cu2+ ion and also showed promising behaviour of nanomaterial. The competitive binding experiments showed the selectivity of Cu2+ ion in presence of other metal ions in aquoues medium. The reversibility studies for chemosensor R1 was investigated and EDTA used as restoring agent. The strong chelation through –N and –O atoms of receptor R1 enhance the change in color triggered selectively by Cu2+ ion and detected by colorimetric methods. The theoretical calculations were employed in order to confirm the experimental observations in the molecular frames.
