127230-66-4Relevant academic research and scientific papers
Synthesis of ABE tricyclic analogues of methyllycaconitine using a Wacker oxidation-aldol strategy to append the B ring to the AE fragment
Barker, David,Brimble, Margaret A.,McLeod, Malcolm,Savage, G. Paul,Wong, David J.
, p. 924 - 931 (2002)
The synthesis of ABE tricyclic analogues 18 of the alkaloid methyllycaconitine 1 is described. The analogues contain the key pharmacophore reputed to be responsible for the biological activity of methyllycaconitine 1, namely, a homocholine motif formed fr
Selective inhibitors of the serine protease plasmin: Probing the S3 and S3′ subsites using a combinatorial library
Xue, Fengtian,Seto, Christopher T.
, p. 6908 - 6917 (2007/10/03)
A combinatorial library of 400 serine protease inhibitors with the general structure Cbz-Xaa-Trp-cyclohexanone-Trp-Yaa-OH has been constructed. The library was synthesized on the solid phase using mix-and-split synthesis, where 20 di
Manganese(III)-Based Oxidative Free-Radical Cyclization of Unsaturated β-Keto Esters, 1,3-Diketones, and Malonate Diesters
Kates, Steven A.,Dombroski, Mark A.,Snider, Barry B.
, p. 2427 - 2436 (2007/10/02)
Oxidative free-radical cyclizations of unsaturated β-keto esters, 1,3-diketones, and malonate diesters with 2 equiv of Mn(OAc)3*2H2O and 1 equiv of Cu(OAc)2*H2O are described.Oxidation of β-keto ester 1 with Mn(III) to enol radical 2 followed by 6-exo cyc
