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127234-71-3

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127234-71-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 127234-71-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,2,3 and 4 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 127234-71:
(8*1)+(7*2)+(6*7)+(5*2)+(4*3)+(3*4)+(2*7)+(1*1)=113
113 % 10 = 3
So 127234-71-3 is a valid CAS Registry Number.

127234-71-3Relevant articles and documents

Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease

Gaeta, Alessandra,Molina-Holgado, Francisco,Kong, Xiao L.,Salvage, Sarah,Fakih, Sarah,Francis, Paul T.,Williams, Robert J.,Hider, Robert C.

, p. 1285 - 1297 (2011/03/23)

A novel class of 2-amido-3-hydroxypyridin-4-one iron chelators is described. These compounds have been designed to behave as suitable molecular probes which will improve our knowledge of the role of iron in neurodegenerative conditions. Neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson disease (PD), can be considered as diverse pathological conditions sharing critical metabolic processes such as protein aggregation and oxidative stress. Interestingly, both these metabolic alterations seem to be associated with the involvement of metal ions, including iron. Iron chelation is therefore a potential therapeutic approach. The physico-chemical (pKa, pFe 3+ and log P) and biological properties (inhibition of iron-containing enzymes) of these chelators have been investigated in order to obtain a suitable profile for the treatment of neurodegenerative conditions. Studies with neuronal cell cultures confirm that the new iron chelators are neuroprotective against β-amyloid-induced toxicity.

Novel synthetic approach to 2-(1′-hydroxyalkyl)- and 2-amido-3-hydroxypyridin-4-ones

Piyamongkol, Sirivipa,Liu, Zu D,Hider, Robert C

, p. 3479 - 3486 (2007/10/03)

Novel methods for the synthesis of high pFe3+ iron chelators, 2-(1′-hydroxyalkyl)- and 2-amido-3-hydroxypyridin-4-ones, have been developed. The products are obtained, via N-oxide intermediates, from either maltol or ethyl maltol.

3-Acylamino-1-[[[(substituted sulfonyl)amino]carbonyl]amino]2-azetidinones

-

, (2008/06/13)

Compounds having the formula and pharmaceutically acceptable salts thereof, exhibit antibacterial activity.

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