127237-69-8Relevant academic research and scientific papers
Selective Reactivity of sp3and sp2 Carbanions of 1-Substituted 1,2,4-Triazoles. A Comparative Approach
Katritzky, Alan R.,Darabantu, Mircea,Aslan, Diana C.,Oniciu, Daniela C.
, p. 4323 - 4331 (1998)
The regioselectivity of lithiation reactions of 1-n-alkyl-, 1-allyl-, and 1-propargyl-1H-1,2,4-triazoles was studied in terms of the products formed by sequential treatment with BuLi and a range of electrophiles.
Isomerizations of N-(α-aminoalkyl)-1,2,4-triazoles and N-(α-aminoalkyl)tetrazoles
Katritzky, Alan R.,Jozwiak, Andrzej,Lue, Ping,Yannakopoulou, Konstantina,Palenik, Gus J.,Zhang, Ze-Ying
, p. 633 - 640 (2007/10/02)
The title compounds exist as equilibrium mixtures of the N-1 and N-2 isomers in solution. However, the crystal structure of 3-(1-hydroxycyclohexyl)-1-(α-pyrrolidinomethyl)-1,2,4-triazole discloses only this isomer in the solid state. Evidence for the natu
Synthesis of 3(5)-substituted 1,2,4-triazoles by lithiation of 1-(1-pyrrolidinomethyl)-1,2,4-triazole
Katritzky, Alan R.,Lue, Ping,Yannakopoulou, Konstantina
, p. 641 - 648 (2007/10/02)
1,2,4-Triazole 1 is readily converted into 3(5)-substituted 1,2,4-triazoles 4 by a three-step sequence: (i) Mannich reaction with formaldehyde and pyrrolidine; (ii) lithiation of 1-(1-pyrrolidinomethyl)-1, 2,4-triazole 2, followed by addition of an electrophile; (iii) deprotection of the N-aminal groups of the N-protected 3-substituted 1,2,4-triazoles 3 using sodium borohydride (NaBH4) in ethanol. 3(5)-Substituted 1,2,4-triazoles 4 result in good overall yields.
