127239-58-1Relevant academic research and scientific papers
Asymmetric transfer hydrogenation of α-amino and α-alkoxy substituted ketones
Kenny, Jennifer A.,Palmer, Matthew J.,Smith, Athene R. C.,Walsgrove, Tim,Wills, Martin
, p. 1615 - 1617 (1999)
Through the use of appropriate protecting groups, the asymmetric transfer hydrogenation of ketones bearing heteroatoms at the α- position may be achieved in high yield and enantioselectivity.
Recent developments in the area of asymmetric transfer hydrogenation
Wills, Martin,Palmer, Matthew,Smith, Athene,Kenny, Jennifer,Walsgrove, Tim
, p. 4 - 18 (2007/10/03)
The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of α-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom.
ENANTIOSPECIFIC SYNTHESIS OF (+)-(R)-1-PHENYL-3-METHYL-1,2,4,5-TETRAHYDROBENZAZEPINE FROM (+)-(S)-N-METHYL-1-PHENYL ETHANOLAMINE (HALOSTACHINE) via ARENE CHROMIUM TRICARBONYL METHODOLOGY
Coote, Steven J.,Davies, Stephen G.,Middlemiss, David,Naylor, Alan
, p. 3581 - 3584 (2007/10/02)
Acid promoted cyclisation of homochiral (R)-N-(3,4-dimethoxyphenethyl) halostachine chromium tricarbonyl is stereospecific, proceeding with retention of configuration, to afford, after decomplexation, homochiral (+)-(R)-1-phenyl-3-methyl-1,2,4,5-tatrahydr
