127245-78-7

Basic information

• Product Name: 3-(2-chloromethylbenzoyl)-2,3-dihydro-2-benzothiazolecarbonitrile
• CAS NO: 127245-78-7
• Molecular Weight: 314.795
• Mol File: 127245-78-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-chloromethylbenzoyl)-2,3-dihydro-2-benzothiazolecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-chloromethylbenzoyl)-2,3-dihydro-2-benzothiazolecarbonitrile(127245-78-7)
• EPA Substance Registry System: 3-(2-chloromethylbenzoyl)-2,3-dihydro-2-benzothiazolecarbonitrile(127245-78-7)

Safety Data

• Hazardous Substances Data: 127245-78-7(Hazardous Substances Data)

Upstream product

• 95479-50-8 2,3-dihydro-3-(4-methylbenzoyl)-2-benzothiazolecarbonitrile 
• 113372-40-0 2,3-dihydro-3-methoxycarbonyl-2-benzothiazolecarbonitrile 
• 95-16-9 1,3-Benzothiazole 
• 7677-24-9 trimethylsilyl cyanide 
• 42908-86-1 2-Chloromethylbenzoyl chloride 

Relevant articles and documents

Reissert Compound Formation with Fused Five-Membered Ring Heterocycles

Reissert compounds have been prepared in high yield from benzothiazole by use of trimethylsilyl cyanide as source of cyanide in a single phase system.Analogues have been made from benzoxazole, indazole and 1-methylindazole but the method was unsuccessful with 1,2-benzisoxazole and pyrazole.Conjugate base alkylation followed by removal of the Reissert grouping provides a route to 2-alkylbenzothiazoles and -benzoxazoles, and 3-alkylated indazoles.Efficient access to pyridobenzothiazole and benzothiazoloisoquinoline derivatives results from appropriate intramolecular cyclisations.A crystal structure determination of 3-benzoyl-2,3-dihydro-2-benzothiazolecarbonitrile is reported.