127264-46-4Relevant academic research and scientific papers
Light induced drug release from a folic acid-drug conjugate
Dcona, M. Michael,Sheldon, Jonathon E.,Mitra, Deboleena,Hartman, Matthew C.T.
, p. 466 - 469 (2017)
A major area of cancer research focuses on improving the specificity of therapeutic agents by engineering drug-delivery vehicles that target overexpressed receptors on tumor cells. One of the most commonly used approaches involves targeting of folate rece
Phosphorylation-dependent kinase-substrate cross-linking
Suwal, Sujit,Pflum, Mary Kay H.
, p. 1627 - 1630 (2010)
"Chemical Equation Presented" Pinning down kinase substrates: The identification of substrates of a particular kinase is fundamental to the elucidation of cell-signaling cascades. This problem has now been addressed by the title approach involving kinase-catalyzed labeling coupled with photo-cross-linking (see scheme). When coupled with mass spectrometry analysis, this strategy can be used to determine the sites of phosphorylation as well as the effector kinase. ADP = adenosine 5'-diphosphate.
CROSS-LINKING ATP ANALOGS
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Page/Page column 4, (2012/10/18)
An adenosine 5′-triphosphate analogs modified at the gamma-phosphate with a reactive reagent. A method of forming the analog by activating a 4-amino benzoic acid, incubating the activated acid to obtain an amine, and coupling the amine with ATP in the presence of water soluble EDCI. A method of detecting the efficacy of a therapeutic by adding a gamma-phosphate modified ATP analog to a protein substrate, reacting the target proteins with the ATP analog, and analyzing the resulting cross-linked product, wherein the amount of product present correlates to the efficacy of the therapeutic is also provided.
