929-59-9

Basic information

• Product Name: 1,8-Diamino-3,6-dioxaoctane
• Synonyms: 2,2’-[1,2-ethanediylbis(oxy)bis-ethanamin;1,8-DIAMINO-3,6-DIOXAOCTANE;1,2-BIS(2-AMINOETHOXY)ETHANE;2,2'-(ETHYLENEDIOXY)BIS(ETHYLAMINE);2,2'-(ETHYLENEDIOXY)DIETHYLAMINE;ETHYLENE GLYCOL BIS(2-AMINOETHYL) ETHER;Amino-PEG2-Amine;1,8-Diamino-3,6-dioxaoctane for synthesis
• CAS NO: 929-59-9
• Molecular Formula: C₆H₁₆N₂O₂
• Molecular Weight: 148.2
• EINECS: 213-203-6
• Product Categories: Aliphatics;Amines
• Mol File: 929-59-9.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 105-109 °C6 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /Liquid
• Density: 1.015 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0369mmHg at 25°C
• Refractive Index: n20/D 1.461(lit.)
• Storage Temp.: Store below +30°C.
• PKA: 9.04±0.10(Predicted)
• Water Solubility: Soluble in 0.4 parts water.
• Sensitive: Hygroscopic
• BRN: 1739187
• CAS DataBase Reference: 1,8-Diamino-3,6-dioxaoctane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-Diamino-3,6-dioxaoctane(929-59-9)
• EPA Substance Registry System: 1,8-Diamino-3,6-dioxaoctane(929-59-9)

Safety Data

• Hazard Codes: C
• Statements: 22-34-42/43-37
• Safety Statements: 23-26-36/37/39-45
• RIDADR: UN 2735 8/PG 2
• WGK Germany: 3
• F: 34
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 929-59-9(Hazardous Substances Data)

Usage

Description

Amino-PEG2-Amine is a crosslinker containing two amino groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

2,2'-(Ethylenedioxy)bis(ethylamine) is used to linker to form conjugates of manganese-doped zinc sulfide nanoparticles with folic acid.

Application

1,8-Diamino-3,6-dioxaoctane is a chelating agent that has been shown to have antibacterial efficacy against gram-positive bacteria. It has been demonstrated to bind to a variety of functionalities such as amines, low energy metals, and hydroxy groups. It has been studied in the synthesis of coordination complexes with a range of geometric structures. The synthesis methods for this compound include solid-phase synthesis and hydrolysis of ethylenediamine. This compound has also been used as an electron donor in fluorescence techniques and morphology studies.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2/p+2

Upstream product

• 153086-78-3 tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate 
• 80322-82-3 triethyleneglycol dimesylate 
• 59086-77-0 1,6-dicyano-2,5-dioxahexane 
• 59559-06-7 1,8-diazido-3,6-dioxaoctane 
• 333-41-5 `Diazinon` 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 31255-10-4 1,2-bis-(2-bromo-ethoxy)-ethane 
• 7664-41-7 ammonia 
• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 112-26-5 1,2-bis(2-chloroethoxy)ethane 
• 31255-11-5 1,8-diphthalimido-3,6-dioxaoctane 

Downstream Products

• 67-42-5 ethylene glycol-bis(2-aminoethyl)-N,N,N'N,'-tetraacetic acid 
• 97569-65-8 1,2-bis-<2-(2-carboxybenzamido)ethane> 
• 23978-10-1 kryptofix 23 
• 153086-78-3 tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate 
• 623575-76-8 5-amino-N-(8-amino-3,6-dioxaoctyl)-2-nitrobenzamide 
• 169744-02-9 {2-[2-(2-amino-ethoxy)-ethoxy]-ethyl}-carbamic acid benzyl ester 

Relevant articles and documents

Method for preparing 1, 8 -diamino -3 and 6 -dioxaoctane through hydrogenation of triethylene glycol

The invention belongs to the field of fine chemical engineering, and provides a method for preparing 1, 8 -diamino -3 and 6 -dioxaoctane through hydrogen ammonification of triethylene glycol. The liquid ammonia and the secondary amine inhibitor are mixed uniformly in the storage tank according to a certain proportion, Ni / Al is injected into the plunger pump. 2 O3 A fixed bed reactor of the catalyst is subjected to ammoniation reaction under a certain process condition. Finally, the product is introduced into the gas-liquid separator to separate 1, 8 - diamino -3, 6 - dioxolane. The invention innovatively utilizes the secondary amine inhibitor and to pre-activate the catalyst to improve the reaction performance and lower the reaction pressure.

Mild deprotection of the: N-tert -butyloxycarbonyl (N -Boc) group using oxalyl chloride

We report a mild method for the selective deprotection of the N-Boc group from a structurally diverse set of compounds, encompassing aliphatic, aromatic, and heterocyclic substrates by using oxalyl chloride in methanol. The reactions take place under room temperature conditions for 1-4 h with yields up to 90percent. This mild procedure was applied to a hybrid, medicinally active compound FC1, which is a novel dual inhibitor of IDO1 and DNA Pol gamma. A broader mechanism involving the electrophilic character of oxalyl chloride is postulated for this deprotection strategy. This journal is

PEGylated atorvastatin derivative and preparation method thereof

The invention relates to a PEGylated atorvastatin derivative and a preparation method thereof. The method mainly comprises the following steps: 1) activating an end group of PEG; 2) enabling the activated PEG to react with atorvastatin to obtain an atorvastatin analogue. The structure of the atorvastatin analogue is: Atorvastatin-L-PEG-L-Atorvastatin, wherein Atorvastatin is atorvastatin; L is anester bond, an amido bond or other linking group; the PEG is residue of monodisperse polyethylene glycol; the structural formula of the atorvastatin analogue is shown in the description, where n is aninteger between 1 and 24. The preparation method has the advantages of short flow, easiness and convenience in reaction operation, few side reactions, low cost, high reaction selectivity, easiness inpurification and higher yield.