1272776-34-7

Basic information

• Product Name: C₁₄H₇ClF₂N₂
• Synonyms: C₁₄H₇ClF₂N₂
• CAS NO: 1272776-34-7
• Molecular Weight: 276.673
• Mol File: 1272776-34-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₇ClF₂N₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₇ClF₂N₂(1272776-34-7)
• EPA Substance Registry System: C₁₄H₇ClF₂N₂(1272776-34-7)

Safety Data

• Hazardous Substances Data: 1272776-34-7(Hazardous Substances Data)

Upstream product

• 1241234-79-6 6-fluoro-2-(3-fluorophenyl)-4-quinazolinone 
• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 63069-49-8 2-amino-5-fluorobenzamide 
• 77206-97-4 2-nitro-5-fluorobenzamide 

Downstream Products

• 1304764-95-1 6-fluoro-2-(3-fluorophenyl)-4-(3-fluoroanilino)quinazoline 
• 1304764-97-3 6-fluoro-2-(3-fluorophenyl)-4-(2-fluoroanilino)quinazoline 
• 1304765-11-4 6-fluoro-2-(3-fluorophenyl)-4-(4-hydroxyanilino)quinazoline 
• 1304764-89-3 6-fluoro-2-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline 
• 1304764-91-7 6-fluoro-2-(3-fluorophenyl)-4-(2-methoxyanilino)quinazoline 
• 1304765-23-8 6-fluoro-2-(3-fluorophenyl)-4-(4-methylanilino)quinazoline 
• 1304765-19-2 6-fluoro-2-(3-fluorophenyl)-4-(3-aminoanilino)quinazoline 
• 1304764-99-5 6-fluoro-2-(3-fluorophenyl)-4-(4-chloroanilino)quinazoline 
• 1304764-87-1 6-fluoro-2-(3-fluorophenyl)-4-(4-methoxyanilino)quinazoline 
• 1304764-85-9 4-anilino-6-fluoro-2-(3-fluorophenyl)quinazoline 
• 1304765-01-2 6-fluoro-2-(3-fluorophenyl)-4-(3-chloroanilino)quinazoline 
• 1304765-21-6 6-fluoro-2-(3-fluorophenyl)-4-(2-aminoanilino)quinazoline 
• 1304765-15-8 6-fluoro-2-(3-fluorophenyl)-4-(2-hydroxyanilino)quinazoline 
• 1304765-03-4 6-fluoro-2-(3-fluorophenyl)-4-(2-chloroanilino)quinazoline 

Relevant articles and documents

The synthesized novel fluorinated compound (LJJ-10) induces death receptor- and mitochondria-dependent apoptotic cell death in the human osteogenic sarcoma U-2 OS cells

We designed the 6-fluoro-2-(3-fluorophenyl)-4-substituted anilinoquinazoline derivatives as less toxic anti-cancer candidates. Our result demonstrated that LJJ-10 has greater cytotoxicity than that of the other compounds in human osteogenic sarcoma U-2 OS cells. LJJ-10-induced apoptosis was associated with enhancing ROS generation, DNA damage, and an increase of the protein levels of Fas, FasL, FADD, caspase-8, cytochrome c, Apaf-1, AIF, Endo G, caspase-9 and caspase-3 in U-2 OS cells. LJJ-10-triggered growth inhibition was significantly attenuated by N-acetylcysteine, cyclosporine A, anti-FasL monoclonal antibody, and caspase-8, -9 and -3 specific inhibitors in U-2 OS cells. We suggest that LJJ-10-induced apoptotic cell death in U-2 OS cells through death receptor- and mitochondria-dependent apoptotic signaling pathways.