1304764-87-1

Basic information

• Product Name: 6-fluoro-2-(3-fluorophenyl)-4-(4-methoxyanilino)quinazoline
• Synonyms: 6-fluoro-2-(3-fluorophenyl)-4-(4-methoxyanilino)quinazoline
• CAS NO: 1304764-87-1
• Molecular Weight: 363.366
• Mol File: 1304764-87-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-fluoro-2-(3-fluorophenyl)-4-(4-methoxyanilino)quinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-2-(3-fluorophenyl)-4-(4-methoxyanilino)quinazoline(1304764-87-1)
• EPA Substance Registry System: 6-fluoro-2-(3-fluorophenyl)-4-(4-methoxyanilino)quinazoline(1304764-87-1)

Safety Data

• Hazardous Substances Data: 1304764-87-1(Hazardous Substances Data)

Upstream product

• 77206-97-4 2-nitro-5-fluorobenzamide 
• 63069-49-8 2-amino-5-fluorobenzamide 
• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 1272776-34-7 C₁₄H₇ClF₂N₂ 
• 104-94-9 4-methoxy-aniline 
• 1241234-79-6 6-fluoro-2-(3-fluorophenyl)-4-quinazolinone 

Relevant articles and documents

The synthesized novel fluorinated compound (LJJ-10) induces death receptor- and mitochondria-dependent apoptotic cell death in the human osteogenic sarcoma U-2 OS cells

We designed the 6-fluoro-2-(3-fluorophenyl)-4-substituted anilinoquinazoline derivatives as less toxic anti-cancer candidates. Our result demonstrated that LJJ-10 has greater cytotoxicity than that of the other compounds in human osteogenic sarcoma U-2 OS cells. LJJ-10-induced apoptosis was associated with enhancing ROS generation, DNA damage, and an increase of the protein levels of Fas, FasL, FADD, caspase-8, cytochrome c, Apaf-1, AIF, Endo G, caspase-9 and caspase-3 in U-2 OS cells. LJJ-10-triggered growth inhibition was significantly attenuated by N-acetylcysteine, cyclosporine A, anti-FasL monoclonal antibody, and caspase-8, -9 and -3 specific inhibitors in U-2 OS cells. We suggest that LJJ-10-induced apoptotic cell death in U-2 OS cells through death receptor- and mitochondria-dependent apoptotic signaling pathways.