127278-00-6Relevant articles and documents
Enhancement of nucleoside cytotoxicity through nucleotide prodrugs
Rose, Jerry D.,Parker, William B.,Someya, Hitoshi,Shaddix, Sue C.,Montgomery, John A.,Secrist III, John A.
, p. 4505 - 4512 (2007/10/03)
A common reason for the lack of cytotoxicity of certain nucleosides is thought to be their inability to be initially activated to the monophosphate level by a nucleoside kinase or other activating enzyme. In a search for other nucleosides that might be wo