127291-63-8

Upstream product

• 320-94-5 2-nitro-4-trifluoromethylbenzoic acid 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Relevant academic research and scientific papers

Silver-promoted decarboxylative sulfonylation of aromatic carboxylic acids with sodium sulfinates

A novel and efficient synthesis of sulfones was developed via a silver-promoted decarboxylative sulfonylation reaction between aromatic carboxylic acids and sodium sulfinates for the first time. The approach features operational simplicity and good functional group compatibility and uses readily available starting materials. Furthermore, mechanistic studies reveal that the decarboxylative sulfonylation reaction is likely to proceed via a radical mechanism.

A NEW GENERAL SYNTHESIS OF SULFONES FROM ALKYL OR ARYL HALIDES AND p-TOLUENESULFONHYDRAZIDE

Here we report the utilization of commercially available p-toluenesulfonhydrazide as a new nucleophilic reagent in displacement reactions with suitable halides for an improved, general synthesis of sulfones.Good results are obtained with primary, secondary, allylic, benzylic, and aromatic halides activated by withdrawing groups.