127322-95-6Relevant academic research and scientific papers
Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids
Lv, Honggui,Xiao, Li-Jun,Zhao, Dongbing,Zhou, Qi-Lin
, p. 6839 - 6843 (2018/09/11)
Herein, we describe the first linear-selective hydroarylation reaction of unactivated alkenes and styrenes with aryl boronic acids, which was achieved by introducing a directing group on the alkenes. This efficient, scalable reaction serves as a method for modular assembly of structurally diverse alkyl arenes, including γ-aryl butyric acid derivatives, which are widely utilized as chemical building blocks for the synthesis of various drugs and other biologically active compounds.
Inhibition of bacterial biofilms and microbial growth with imidazole derivatives
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Page/Page column 30; 31, (2016/04/26)
Disclosure is provided for imidazole derivative compounds useful to inhibit the formation of biofilms and/or inhibit microbial growth, compositions including these compounds, devices including these compounds, and methods of using the same.
α-Diazo-β-ketonitriles: Uniquely reactive substrates for arene and alkene cyclopropanation
Nani, Roger R.,Reisman, Sarah E.
supporting information, p. 7304 - 7311 (2013/06/27)
An investigation of the intramolecular cyclopropanation reactions of α-diazo-β-ketonitriles is reported. These studies reveal that α-diazo-β-ketonitriles exhibit unique reactivity in their ability to undergo arene cyclopropanation reactions; other similar acceptor-acceptor- substituted diazo substrates instead produce mixtures of C-H insertion and dimerization products. α-Diazo-β-ketonitriles also undergo highly efficient intramolecular cyclopropanation of tri- and tetrasubstituted alkenes. In addition, the α-cyano-α-ketocyclopropane products are demonstrated to serve as substrates for SN2, SN2′, and aldehyde cycloaddition reactions.
A nitroenolate approach to the synthesis of 4,5-disubstituted-2- aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity
Su, Zhaoming,Rogers, Steven A.,McCall, W. Steve,Smith, Alicia C.,Ravishankar, Sindhu,Mullikin, Trey,Melander, Christian
scheme or table, p. 2814 - 2822 (2010/08/21)
A library of 4,5-disubstituted-2-aminoimidazoles was synthesized using a nitroenolate route and then screened for antibiofilm and antimicrobial activity. These compounds displayed notable biofilm dispersal and planktonic microbicidal activity against various Gram-positive and Gram-negative bacteria.
