1273319-46-2Relevant academic research and scientific papers
Triazole incorporated pyridazinones as a new class of antihypertensive agents: Design, synthesis and in vivo screening
Siddiqui, Anees A.,Mishra, Ravinesh,Shaharyar, Mohammad,Husain, Asif,Rashid, Mohd.,Pal, Palash
, p. 1023 - 1026 (2011/03/21)
A number of 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5- dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were designed and synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-4u) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e, 4i and 4k showed appreciable antihypertensive activity comparable with that of standard hydralazine and propranolol.
