1273321-44-0Relevant articles and documents
Enantioselective organocatalytic Michael-Wittig-Michael-Michael reaction: Dichotomous construction of pentasubstituted cyclopentanecarbaldehydes and pentasubstituted cyclohexanecarbaldehydes
Hong, Bor-Cherng,Nimje, Roshan Y.,Lin, Cheng-Wei,Liao, Ju-Hsiou
, p. 1278 - 1281 (2011/06/09)
Michael addition of carbethoxymethylenetriphenylphosphorane (a Wittig reagent) to nitroalkenes, followed by a reaction with ethyl formylformate and cinnamaldehydes, or formaldehyde and cinnamaldehydes, provided the respective pentasubstituted cyclopentanecarbaldehydes bearing a quaternary carbon center and pentasubstituted cyclohexanecarbaldehydes having five contiguous stereocenters with excellent enantioselectivities (up to >99% ee).