1273323-67-3Relevant articles and documents
Optimization and Development of a Scalable Palladium-Catalyzed C-H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator
Yin, Jianpeng,Zhan, Desheng,Ma, Hui,Liu, Huanan,Yu, Lifang,Zhang, Yangming,Nan, Fajun
, p. 2260 - 2269 (2021/10/21)
Adenosine 5′-monophosphate-activated protein kinase (AMPK) activator YLF466D is a promising preclinical drug candidate to treat metabolic diseases and myocardial ischemia-reperfusion injury (MIRI). Herein, we report our efforts on optimization and develop
Advanced palladium free approach to the synthesis of substituted alkene oxindoles: Via aluminum-promoted Knoevenagel reaction
Novikova, Daria S.,Grigoreva, Tatyana A.,Zolotarev, Andrey A.,Garabadzhiu, Alexander V.,Tribulovich, Vyacheslav G.
, p. 34543 - 34551 (2018/10/24)
A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.
NOVEL ALKENE OXINDOLE DERIVATIVES
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, (2011/04/18)
The present invention provides compounds of formula (I), as well as pharmaceutical acceptable salt thereof, wherein R1 to R7 have the significance given herein. The compounds are useful in the treatment of prophylaxis of diseases tha
