1273323-67-3

Usage

Uses

Used in Pharmaceutical Industry:
YLF-466D is used as a pharmaceutical agent for activating AMP-activated protein kinase (AMPK), which is involved in the regulation of cellular energy homeostasis. This activation can lead to potential therapeutic benefits in treating various diseases and conditions related to energy metabolism.
Used in Metabolic Research:
YLF-466D is used as a research tool for studying the role of AMPK in cellular energy homeostasis. By activating AMPK, researchers can gain insights into the mechanisms of energy regulation and develop new strategies for managing metabolic disorders.
Used in Drug Development:
YLF-466D is used as a lead compound in the development of new drugs targeting AMPK activation. Its ability to modulate cellular energy balance makes it a promising candidate for the treatment of diseases associated with energy metabolism dysregulation, such as obesity, type 2 diabetes, and neurodegenerative disorders.

Upstream product

• 536-74-3 phenylacetylene 
• 103-71-9 phenyl isocyanate 
• 1428422-76-7 3-{3-[(4-chlorophenyl)-phenyl-methylene]-2-oxo-2,3-dihydro-indol-1-ylmethyl}-benzoic acid methyl ester 
• 59-48-3 2-oxoindole 
• 134-85-0 4-chlorobenzophenone 
• 1129-28-8 3-methoxycarbonylbenzyl bromide 
• 1273324-41-6 3-{[phenyl-(3-phenyl-propynoyl)-amino]-methyl}-benzoic acid methyl ester 
• 7342-02-1 3-phenylpropynoic acid phenylamide 
• 637-44-5 phenylpropyolic acid 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Optimization and Development of a Scalable Palladium-Catalyzed C-H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator

Adenosine 5′-monophosphate-activated protein kinase (AMPK) activator YLF466D is a promising preclinical drug candidate to treat metabolic diseases and myocardial ischemia-reperfusion injury (MIRI). Herein, we report our efforts on optimization and develop

Activating Effect of 3-Benzylidene Oxindoles on AMPK: From Computer Simulation to High-Content Screening

AMP-activated protein kinase (AMPK) is currently the subject of intensive study and active discussions. AMPK performs its functions both at the cellular level, providing the switch between energy-consuming and energy-producing processes, and at the whole

Advanced palladium free approach to the synthesis of substituted alkene oxindoles: Via aluminum-promoted Knoevenagel reaction

A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.

Development of novel alkene oxindole derivatives as orally efficacious AMP-activated protein kinase activators

Adenosine 5′-monophosphate-activated protein kinase (AMPK) is emerging as a promising drug target for its regulatory function in both glucose and lipid metabolism. Compound PT1 (5) was originally identified from high throughput screening as a small molecu

NOVEL ALKENE OXINDOLE DERIVATIVES

The present invention provides compounds of formula (I), as well as pharmaceutical acceptable salt thereof, wherein R1 to R7 have the significance given herein. The compounds are useful in the treatment of prophylaxis of diseases tha

ALKENE OXINDOLE DERIVATIVES AND THEIR USES TO TREAT OBESITY, DIABETES AND HYPERLIPIDEMIA

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R7 have the significance given in claim 1, can be used as a medicament.

NOVEL ALKENE OXINDOLE DERIVATIVES

A compound of formula (I), the pharmaceutically acceptable salt, the pharmaceutical composition, the preparation method and the use thereof.