7342-02-1Relevant articles and documents
Copper-catalyzed domino reaction between terminal alkynes, isocyanates, and oxiranes: An atom-economic route to morpholine derivatives
Beigi-Somar, Vahid,Homami, Seyed Saied,Ghazanfarpour-Darjani, Majid,Monzavi, Amirhossein
, p. 140 - 150 (2020)
In situ generated copper acetylides react with isocyanates and oxiranes to form a decent range of morpholine derivatives. The reactions proceeded with acceptable yields and excellent regioselectivity. The presence of oxygen and moisture completely inhibit
Optimization and Development of a Scalable Palladium-Catalyzed C-H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator
Yin, Jianpeng,Zhan, Desheng,Ma, Hui,Liu, Huanan,Yu, Lifang,Zhang, Yangming,Nan, Fajun
, p. 2260 - 2269 (2021/10/21)
Adenosine 5′-monophosphate-activated protein kinase (AMPK) activator YLF466D is a promising preclinical drug candidate to treat metabolic diseases and myocardial ischemia-reperfusion injury (MIRI). Herein, we report our efforts on optimization and develop
Synthesis of Succinimides via Intramolecular Alder-Ene Reaction of 1,6-Enynes
Chen, Xia,Lu, Yuling,Guan, Zhenhua,Gu, Lianghu,Chen, Chunmei,Zhu, Hucheng,Luo, Zengwei,Zhang, Yonghui
supporting information, p. 3173 - 3178 (2021/05/05)
A novel and convenient method has been developed for the facile synthesis of functionalized succinimide derivatives via intramolecular Alder-ene reaction of 1,6-enynes. This reaction features mild and metal-free reaction conditions, which offers a green and efficient entry to synthetically important succinimide scaffolds. Preliminary mechanistic studies suggest that a diradical intermediate might be involved in this transformation.
