1273331-01-3Relevant academic research and scientific papers
A parallel Ugi reaction at students laboratories in the ural and Moscow
Mironov,Babaev
, p. 2647 - 2654 (2010)
A four-component Ugi reaction was adapted for students education. To this end, a series of almost odorless aromatic isonitriles with donor substituents was reacted with a specific carboxylic acid, phthaloyl glycine, to obtain poorly soluble (although nicely crystallized) products. The process was performed and compared in two versions by using (1) a standard centrifuge for parallel separation of precipitates and (2) parallel filtration with SynCore apparatus. It is shown for a broad series of aliphatic ketones and benzyl amines that the yields are satisfactory and the products require no further purification. Pleiades Publishing, Ltd., 2010.
