1273547-05-9

Basic information

• Product Name: (3S)-(E)-N-Boc-N-[2-[2-[3-(tert-butyldimethylsilyloxy)but-1-enyl]-5-pivaroyloxyphenyl]ethyl]amine
• Synonyms: (3S)-(E)-N-Boc-N-[2-[2-[3-(tert-butyldimethylsilyloxy)but-1-enyl]-5-pivaroyloxyphenyl]ethyl]amine
• CAS NO: 1273547-05-9
• Molecular Weight: 505.77
• Mol File: 1273547-05-9.mol

Chemical Properties

• CAS DataBase Reference: (3S)-(E)-N-Boc-N-[2-[2-[3-(tert-butyldimethylsilyloxy)but-1-enyl]-5-pivaroyloxyphenyl]ethyl]amine(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-(E)-N-Boc-N-[2-[2-[3-(tert-butyldimethylsilyloxy)but-1-enyl]-5-pivaroyloxyphenyl]ethyl]amine(1273547-05-9)
• EPA Substance Registry System: (3S)-(E)-N-Boc-N-[2-[2-[3-(tert-butyldimethylsilyloxy)but-1-enyl]-5-pivaroyloxyphenyl]ethyl]amine(1273547-05-9)

Safety Data

• Hazardous Substances Data: 1273547-05-9(Hazardous Substances Data)

Upstream product

• 1273546-92-1 C₁₃H₁₄BrNO₂ 
• 1198272-03-5 (S,E)-tert-butyldimethyl((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-2-yl)oxy)silane 
• 1273546-91-0 N-Boc-N-[ 2-(2-bromo-5-pivaroyloxy-phenyl)ethyl]amine 
• 150406-34-1 (S)-3-(tert-butyldimethylsilyloxy)but-1-yne 
• 3282-30-2 pivaloyl chloride 
• 51506-70-8 (2-bromo-5-hydroxy-phenyl)-acetonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1273547-15-1 (3S)-(Z)-N-Boc-N-[2-[2-(3-hydroxy-1-butenyl)phenyl]ethyl]amine 

Relevant articles and documents

Synthesis of chiral 1-substituted tetrahydroisoquinolines by the intramolecular 1,3-chirality transfer reaction catalyzed by Bi(OTf)3

The intramolecular 1,3-chirality transfer reaction of chiral amino alcohols 1 with 99% ee was developed to construct chiral 1-substituted tetrahydroisoquinoline 2. Bi(OTf)3 (10 mol %)-catalyzed cyclization of 1 (R = H) afforded (S)-1-(E)-propenyl tetrahydroisoquinoline 2 (R = H) in 83% yield with a ratio of 98:2. The stereochemistry at the newly formed chiral center was produced by a syn SN2′-type process. In this reaction, the substituent on the benzene ring of 1 significantly affected the reactivities and selectivities. A plausible reaction mechanism was proposed.