1273552-02-5

Upstream product

• 326913-94-4 6-methoxy-3-[1-(phenylhydrazono)-ethyl]-chromen-2-one 
• 13252-80-7 3-acetyl-6-methoxycoumarin 
• 100-63-0 phenylhydrazine 
• 1273551-97-5 C₁₈H₁₆N₂O₃ 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

Copper-catalyzed cyclization of 3-acylcoumarin hydrazone using air as the oxidant: Efficient synthesis of pyrazole-fused coumarin derivatives

An efficient, convenient Cu-catalyzed formation of chromeno[4,3-c]pyrazol-4(1H)-ones is reported. In this atom economic process, readily available 3-acylcoumarin hydrazone is oxidative cyclized by direct C-N bond formation. Air has been successfully used

Synthesis, anticancer activity and photophysical properties of novel substituted 2-oxo-2H-chromenylpyrazolecarboxylates

2-Oxo-2H-chromenylpyrazolecarboxylates (8a-h and 12a-zb) have been synthesized by [3 + 2] cycloaddition of 2H-chromenophenylhydrazones (7a-h and 11a-w) with diethyl/dimethylbut-2-ynedioates. Phenylchromeno[4,3-c]pyrazol-4(1H) -ones (13i-n) were prepared from corresponding phenylhydrazones (7a-h) with catalytic amount of piperidine in presence of pyridine as a solvent at 100°C. All the synthesized compounds (8a-h, 12a-zb and 13a-n) were screened for anticancer activity against three human cancer cell lines such as prostate (DU-145), lung adenocarcinoma (A549), and cervical (HeLa) by standard MTT assay method. Further, photophysical properties (UV and fluorescence) for these compounds were discussed.

X-ray supramolecular structure, NMR spectroscopy and synthesis of 3-methyl-1-phenyl-1H-chromeno[4,3-c]pyrazol-4-ones formed by the unexpected cyclization of 3-[1-(phenylhydrazono)ethyl]-chromen-2-ones

The molecular structures of nine 3-methyl-1-phenyl-1H-chromeno[4,3-c] pyrazol-4-one isomers, obtained by the oxidative cyclization of the corresponding 1-phenylhydrazono chromen-2-ones with copper acetate as catalyst, are reported. The molecular and supra