127356-26-7

Basic information

• Product Name: 6-METHOXY-3,4-PYRIDINEDIAMINE
• Synonyms: 6-METHOXY-3,4-PYRIDINEDIAMINE;6-methoxypyridine-3,4-diamine;3,4-Pyridinediamine,6-methoxy-(9CI);3,4-Diamino-6-methoxypyridine;6-Methoxypyridin-3,4-diaMine;3,4-DiaMino-6-Methoxypyridine hydrochloride
• CAS NO: 127356-26-7
• Molecular Formula: C₆H₉N₃O
• Molecular Weight: 139.15516
• Product Categories: PYRIDINE
• Mol File: 127356-26-7.mol

Chemical Properties

• Boiling Point: 368.23 °C at 760 mmHg
• Flash Point: 176.5 °C
• Appearance: /
• Density: 1.251 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.34±0.42(Predicted)
• CAS DataBase Reference: 6-METHOXY-3,4-PYRIDINEDIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHOXY-3,4-PYRIDINEDIAMINE(127356-26-7)
• EPA Substance Registry System: 6-METHOXY-3,4-PYRIDINEDIAMINE(127356-26-7)

Safety Data

• Hazardous Substances Data: 127356-26-7(Hazardous Substances Data)

Usage

Uses

Used in Hair Dye and Colorant Industry:
6-Methoxy-3,4-pyridinediamine is used as a key ingredient in hair dyes and colorants for its ability to impart color to hair. It is valued for its effectiveness in creating a range of shades and tones, enhancing the visual appeal of hair products.
However, due to its classification as an aromatic amine, it is crucial to consider the health implications associated with its use. 6-METHOXY-3,4-PYRIDINEDIAMINE may cause skin and eye irritation, and there are concerns regarding its potential carcinogenic properties. Therefore, it is essential to incorporate this chemical into hair dyes and colorants with proper safety measures, including warnings on product labels and the implementation of regulatory standards to minimize exposure and risk to consumers and professionals in the industry.

Upstream product

• 43016-99-5 Tin (II) chloride 
• 127356-38-1 4-amino-2-methoxy-5-nitropyridine 
• 14432-12-3 4-Amino-2-chloropyridine 
• 2604-39-9 4-amino-2-chloro-5-nitropyridine 

Downstream Products

• 127356-30-3 6-Methoxy-2-(2-methoxy-4-methylsulfanyl-phenyl)-1H-imidazo[4,5-c]pyridine 
• 127356-08-5 2-(4-Methanesulfinyl-2-methoxy-phenyl)-6-methoxy-1H-imidazo[4,5-c]pyridine 

Relevant articles and documents

Polycyclic compound for inhibiting RNA helicase DHX33

The invention relates to a polycyclic compound for inhibiting RNA helicase DHX33. In particular, the invention relates to a compound shown as a formula I or a pharmaceutically acceptable form thereof, a pharmaceutical composition containing the compound, a preparation method of the compound, and medical application of the compound to prevention and/or treatment of DHX33 related diseases.

Application RNA deferase DHX33 inhibitor in preparation of medicine for treating liver cancer

The invention belongs to the field of biological medicine, and discloses application of RNA deferase DHX33 inhibitor in preparation of a medicament for treating liver cancer. The invention establishes an important role DHX33 protein in developing the liver cancer, and the provided small molecule compound has the effect of inhibiting DHX33 helicase activity and further inhibits the synthesis of mevalonate by DHX33 regulation and control. The small molecule compound can remarkably inhibit the growth of liver cancer cells in vitro and in vivo, and has important medical development value.

Hepatitis C virus inhibitors

Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Hepatitis C Virus Inhibitors

Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Thiophene-imidazopyridines

The invention relates to thiophene-imidazopyridine compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of PIk1

Diaminopyridine compounds and methods of use

The present invention relates to compositions and method for inhibiting nonenzymatic cross-linking (protein aging) which contain diaminopyridines and derivates thereof. Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

Inotropic 'A' ring substituted sulmazole and isomazole analogues

A series of 'A' ring substituted sulmazole and isomazole analogues have been prepared and evaluated as inotropic agents. pK(A)'s, protonation sites, and log P values were measured for selected compounds and their electronic properties were calculated. No simple correlation between inotropic activity and pK(A), protonation site, or log P value was observed. However, in vitro inotropism did correlate with the calculated charge density of the 'B' ring imidazo nitrogen atom. The 6-position of sulmazole appeared to be the most tolerant toward substituents, th 6-amino derivative 7 being a more potent inotrope than sulmazole itself. 4-Methoxyisomazole 13 had comparable in vivo inotropic properties to those of isomazole.