1273583-89-3Relevant academic research and scientific papers
Enantioselective primary amine catalyzed aldol-type construction of trifluoromethylated tertiary alcohols
Yang, Wei,Cui, Yu-Ming,Zhou, Wei,Li, Li,Yang, Ke-Fang,Zheng, Zhan-Jiang,Lu, Yixin,Xu, Li-Wen
, p. 1461 - 1465 (2014)
It was found that the cinchona-derived primary amines and their combined catalyst systems with chiral organic acid or Lewis acid have been successfully applied in the cross-aldol reaction of trifluoromethyl ketones and aliphatic ketones. Excellent yields
Tripeptide-catalyzed asymmetric aldol reaction of trifluoromethylated aromatic ketones with acetone
Kon, Kazumasa,Kohari, Yoshihito,Murata, Miki
, p. 841 - 847 (2019/08/01)
The development of H-Pro-Gly-Ala-OH (3d) to realize an inexpensive and simple organocatalytic system for the direct asymmetric aldol reaction of trifluoromethylated aromatic ketone 1 with acetone was achieved. The 3d-catalyzed aldol reaction of 1a-1j prov
Fine-tuning the structures of chiral diamine ligands in the catalytic asymmetric aldol reactions of trifluoromethyl aromatic ketones with linear aliphatic ketones
Zong, Hua,Huang, Huayin,Bian, Guangling,Song, Ling
, p. 11768 - 11773 (2015/01/16)
In this work, we thoroughly investigated the effect of structural differentiation of a series of N,N-disubstituted chiral diamine ligands on the catalytic asymmetric aldol reactions between trifluoromethyl ketones and linear aliphatic ketones for the cons
Highly enantioselective organocatalytic trifluoromethyl carbinol synthesis-a caveat on reaction times and product isolation
Duangdee, Nongnaphat,Harnying, Wacharee,Rulli, Giuseppe,Neudoerfl, Joerg-M.,Groeger, Harald,Berkessel, Albrecht
experimental part, p. 11196 - 11205 (2012/08/28)
Aldol reactions with trifluoroacetophenones as acceptors yield chiral α-aryl, α-trifluoromethyl tertiary alcohols, valuable intermediates in organic synthesis. Of the various organocatalysts examined, Singh's catalyst [(2S)-N-[(1S)-1-hydroxydiphenylmethyl
Construction of tertiary alcohols bearing perfluoroalkyl chains catalyzed by prolinamide-thioureas
Kokotos, Christoforos G.
experimental part, p. 1131 - 1135 (2012/03/12)
A systematic study to evaluate the ability of various organocatalysts to catalyze the aldol reaction between acetone and 2,2,2-trifluoromethyl-1- phenylethanone was undertaken. Benchmark organocatalysts failed to catalyzethis reaction. However, a prolinam
N-(heteroarenesulfonyl)prolinamides-catalyzed aldol reaction between acetone and aryl trihalomethyl ketones
Hara, Noriyuki,Tamura, Ryota,Funahashi, Yasuhiro,Nakamura, Shuichi
supporting information; experimental part, p. 1662 - 1665 (2011/05/11)
Enantiomerically enriched trihalomethyl-substituted alcohols having a quaternary chiral carbon center can be prepared by the catalytic enantioselective cross-aldol reaction of acetone with trihalomethyl ketones by using N-(8-quinolinesulfonyl)prolinamide as an organocatalyst. The MO calculations elucidate that the hydrogen bonding between the sulfonimide proton and the 8-quinolyl nitrogen atom plays an important role in exerting the enantioselectivity of the reaction.
