1273583-99-5Relevant academic research and scientific papers
Construction of tertiary alcohols bearing perfluoroalkyl chains catalyzed by prolinamide-thioureas
Kokotos, Christoforos G.
experimental part, p. 1131 - 1135 (2012/03/12)
A systematic study to evaluate the ability of various organocatalysts to catalyze the aldol reaction between acetone and 2,2,2-trifluoromethyl-1- phenylethanone was undertaken. Benchmark organocatalysts failed to catalyzethis reaction. However, a prolinam
N-(heteroarenesulfonyl)prolinamides-catalyzed aldol reaction between acetone and aryl trihalomethyl ketones
Hara, Noriyuki,Tamura, Ryota,Funahashi, Yasuhiro,Nakamura, Shuichi
supporting information; experimental part, p. 1662 - 1665 (2011/05/11)
Enantiomerically enriched trihalomethyl-substituted alcohols having a quaternary chiral carbon center can be prepared by the catalytic enantioselective cross-aldol reaction of acetone with trihalomethyl ketones by using N-(8-quinolinesulfonyl)prolinamide as an organocatalyst. The MO calculations elucidate that the hydrogen bonding between the sulfonimide proton and the 8-quinolyl nitrogen atom plays an important role in exerting the enantioselectivity of the reaction.
