127399-79-5

Upstream product

• 100-39-0 benzyl bromide 
• 16239-18-2 1,6-dibromo-2-naphthol 
• 100-44-7 benzyl chloride 

Downstream Products

• 1365958-40-2 2-(benzyloxy)-6-(3-(benzyloxy)phenyl)-1-bromonaphthalene 
• 1365958-07-1 N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-3-methylbenzenesulfonamide 
• 1365958-04-8 N-(3-(2-(hydroxy)-6-(3-(hydroxy)phenyl)naphthalen-1-yl)phenyl)-2-methylbenzenesulfonamide 
• 1365958-01-5 N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-hydroxybenzenesulfonamide 
• 1365957-98-7 N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-3-hydroxybenzenesulfonamide 
• 1365957-96-5 N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-fluorobenzenesulfonamide 
• 1365957-94-3 N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-3-fluorobenzenesulfonamide 
• 1365957-92-1 N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-2-fluorobenzenesulfonamide 
• 1365957-90-9 N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-4-cyanobenzenesulfonamide 
• 1365957-87-4 N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-3-cyanobenzenesulfonamide 
• 1365957-85-2 N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-2,4-dinitrobenzenesulfonamide 
• 1365957-83-0 N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)-2-nitrobenzenesulfonamide 
• 1365957-80-7 N-(3-(2-hydroxy-6-(3-hydroxyphenyl)naphthalen-1-yl)phenyl)benzenesulfonamide 
• 1365959-02-9 N-(3-(2-(benzyloxy)-6-(3-(benzyloxy)phenyl)naphthalen-1-yl)phenyl)-2,2,2-trifluoroethanesulfonamide 

Relevant academic research and scientific papers

Rh(II)-Catalyzed Synthetic Strategy for Diverse and Functionalized Halonaphthalenyl Ethers and Esters from Diazo Compounds and Its Application to Polyaromatic Compounds

An efficient and simple synthesis of various functionalized halonaphthalenyl ethers and esters in moderate to good yield was achieved via rhodium(II)-catalyzed reaction of readily available diazo compounds with benzyl halides or acid halides. This methodology has several advantages, such as ease of handling, mild reaction conditions, bromine- or chlorine-free route, and the use of an effective catalyst. The synthesized compounds were further converted into valuable polyaromatic compounds using the Suzuki reaction.

Lead optimization of 17β-HSD1 inhibitors of the (hydroxyphenyl) naphthol sulfonamide type for the treatment of endometriosis

The reduction of estrone to estradiol, the most potent estrogen in human, is catalyzed by 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1). A promising approach for the treatment of estrogen-dependent diseases is the reduction of intracellular estradiol formation by inhibition of 17β-HSD1. For the species-specific optimization of the (hydroxyphenyl)naphthols, a combinatorial approach was applied and enhanced by a focused synthesis that resulted in the aromatic-substituted (hydroxyphenyl)naphthol sulfonamides. Rigidification of 12 led to the 4-indolylsulfonamide 30, which is a highly active and selective human 17β-HSD1 inhibitor, as well as a highly potent and selective inhibitor of 17β-HSD1 from Callithrix jacchus. It shows no affinity to the estrogen receptors I?± and β and good intracellular activity (T47D). Thus, compound 30 shows good properties for further ADMET studies and might be a candidate for the in vivo proof of concept in C. jacchus.

Monomethyl Ether Derivatives of 7,8-Dihydroxy- and 8,9-Dihydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzoquinolines as Possible Products of Metabolism by Catechol-O-methyltransferase

In order to facilitate identification of possible metabolites arising from in vitro action of catechol-O-methyltransferase upon 7,8-dihydroxy- and 8,9-dihydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzoquinolines (11, 12), all four possible monomethyl ether derivatives have been synthesized.Incubation of 11 and 12 with the enzyme revealed that the 8,9-dihydroxy positional isomer 12 (which contains the dopamine moiety held in the β conformation) but not the 7,8-dihydroxy isomer 11 (which holds the dopamine moiety in the α conformation) was a substrate for theenzyme.The sole detectable product of 12 was 8-hydroxy-9-methoxy derivative 15 in which the "meta" hydroxy group of the dopamine moiety is etherified.