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4-Pyrazin-2-ylbenzaldehyde is a chemical compound with the formula C11H8N2O. It is an aroma compound that emits a herbal-sweet-strong creamy odor. It is not a natural compound and does not naturally occur in the environment. It is commonly used in the synthesis of various pharmaceuticals and other organic compounds.

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  • 127406-08-0 Structure
  • Basic information

    1. Product Name: 4-PYRAZIN-2-YLBENZALDEHYDE
    2. Synonyms: 4-(2-PYRAZINYL)BENZENECARBALDEHYDE;4-PYRAZIN-2-YLBENZALDEHYDE;4-(Pyrazin-2-yl)benzenecarboxaldehyde
    3. CAS NO:127406-08-0
    4. Molecular Formula: C11H8N2O
    5. Molecular Weight: 184.19
    6. EINECS: 604-604-1
    7. Product Categories: N/A
    8. Mol File: 127406-08-0.mol
  • Chemical Properties

    1. Melting Point: 84-87°
    2. Boiling Point: 347.2±32.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.205±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. PKA: 0.23±0.10(Predicted)
    10. CAS DataBase Reference: 4-PYRAZIN-2-YLBENZALDEHYDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-PYRAZIN-2-YLBENZALDEHYDE(127406-08-0)
    12. EPA Substance Registry System: 4-PYRAZIN-2-YLBENZALDEHYDE(127406-08-0)
  • Safety Data

    1. Hazard Codes: Xi,Xn
    2. Statements: 22-36
    3. Safety Statements: 26
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 127406-08-0(Hazardous Substances Data)

127406-08-0 Usage

Uses

Used in Pharmaceutical Industry:
4-Pyrazin-2-ylbenzaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals for its versatile chemical properties and potential therapeutic applications.
Used in Organic Chemistry:
4-Pyrazin-2-ylbenzaldehyde is used as a building block in the synthesis of other organic compounds, contributing to the development of new materials and chemical products.
Used in Chemosensing Applications:
The derivative of 4-Pyrazin-2-ylbenzaldehyde, Phenylhydrazone, is used in the practice of chemosensing ensemble for the detection of nerve gases and pesticides, highlighting its potential in environmental and safety monitoring.
Safety Measures:
4-Pyrazin-2-ylbenzaldehyde may pose hazards if improperly handled or used. Therefore, appropriate safety measures should be followed to ensure safe handling and usage in various applications.

Check Digit Verification of cas no

The CAS Registry Mumber 127406-08-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,4,0 and 6 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 127406-08:
(8*1)+(7*2)+(6*7)+(5*4)+(4*0)+(3*6)+(2*0)+(1*8)=110
110 % 10 = 0
So 127406-08-0 is a valid CAS Registry Number.

127406-08-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-PYRAZIN-2-YLBENZALDEHYDE

1.2 Other means of identification

Product number -
Other names 4-Pyrazin-2-yl-benzaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127406-08-0 SDS

127406-08-0Relevant articles and documents

Biarylcarboxybenzamide derivatives as potent vanilloid receptor (VR1) antagonistic ligands

Park, Hyeung-Geun,Choi, Ji-Yeon,Kim, Mi-Hyun,Choi, Sea-Hoon,Park, Mi-Kyung,Lee, Jihye,Suh, Young-Ger,Cho, Hawon,Oh, Uhtaek,Kim, Hee-Doo,Joo, Yung Hyup,Shin, Song Seok,Kim, Jin Kwan,Jeong, Yeon Su,Koh, Hyun-Ju,Park, Young-Ho,Jew, Sang-Sup

, p. 631 - 634 (2005)

Seventeen biarylcarboxybenzamide derivatives were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor (VR1) in rat DRG neurons. The replacement of the piperazine moiety of the lead compound 1 with phenyl ring showed quite enhanced antagonistic activity. Among the prepared derivatives, N-(4-tert-butylphenyl)-4-pyridine-2-yl-benzamide (2, IC 50 = 31 nM) and N-(4-tert-butylphenyl)-4-(3-methylpyridine-2-yl) benzamide (3g, IC50 = 31 nM), showed 5-fold higher antagonistic activity than 1 in 45Ca2+-influx assay.

Synthesis, crystal structures and catalytic activity of three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with N-heterocyclic carbenes (NHCs) and triphenylphosphine

Xu, Chen,Li, Hong-Mei,Wang, Zhi-Qiang,Fu, Wei-Jun

, p. 11 - 15 (2014)

Three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with NHCs and PPh3 1-3 have been synthesized and characterized by elemental analysis, IR, NMR and single-crystal X-ray diffraction. Their application to Suzuki coupling of phenylboro

A general catalyst for Suzuki-Miyaura and Sonogashira reactions of aryl and heteroaryl chlorides in water

Peng, Hui,Chen, Ya-Qin,Mao, Shu-Lan,Pi, Yun-Xiao,Chen, You,Lian, Ze-Yu,Meng, Tong,Liu, Sheng-Hua,Yu, Guang-Ao

supporting information, p. 6944 - 6952 (2014/09/29)

We report the synthesis of 2-(3-sulfonatomesityl)-5-sulfonatoindenyl) dicyclohexylphosphine hydrate sodium salt and its use in palladium-catalyzed Suzuki-Miyaura and Sonogashira coupling reactions in water (and biphasic water-organic solvent mixtures) to prepare a variety of functionalized biaryls and aryl alkynes in excellent yield. This journal is the Partner Organisations 2014.

Synthesis, crystal structures and catalytic activity of three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with N-heterocyclic carbenes (NHCs) and triphenylphosphine

Xu, Chen,Li, Hong-Mei,Wang, Zhi-Qiang,Fu, Wei-Jun

, p. 11 - 15 (2014/12/11)

Three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with NHCs and PPh3 1-3 have been synthesized and characterized by elemental analysis, IR, NMR and single-crystal X-ray diffraction. Their application to Suzuki coupling of phenylboronic acid co

Synthesis, crystal structures and catalytic activity of three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with N-heterocyclic carbenes (NHCs) and triphenylphosphine

Xu, Chen,Li, Hong-Mei,Wang, Zhi-Qiang,Fu, Wei-Jun

, p. 11 - 15 (2015/02/19)

Three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with NHCs and PPh31-3 have been synthesized and characterized by elemental analysis, IR, NMR and single-crystal X-ray diffraction. Their application to Suzuki coupling of phenylboron

11,12-Cyclic thiocarbamate macrolide antibacterial agents

-

Page/Page column 29-30, (2010/02/14)

The present invention is directed to novel macrolide antibacterial agents and processes for preparing them. The present invention is further directed to pharmaceutical compositions containing the novel macrolide antibacterial agents disclosed herein and t

Methods of treatment using an EP2 selective receptor agonist

-

Page/Page column 48, (2010/02/13)

The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, facilitating the growth of tooth enamel or finger or toe nails, treating glaucoma, treating ocular hypertension, and repairing damage caused by metastatic bone disease using an EP2 selective receptor agonist.

3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents

-

Page/Page column 61, (2010/02/05)

3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents of the formula: wherein R1, W, R3, R4, R5, R6, X, X′, and Z are as described herein and in which the substituents have th

6-O-acyl ketolide antibacterials

-

, (2008/06/13)

6-O-Acyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, W, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

Method for treating glaucoma

-

, (2008/06/13)

Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.

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