127406-08-0Relevant articles and documents
Biarylcarboxybenzamide derivatives as potent vanilloid receptor (VR1) antagonistic ligands
Park, Hyeung-Geun,Choi, Ji-Yeon,Kim, Mi-Hyun,Choi, Sea-Hoon,Park, Mi-Kyung,Lee, Jihye,Suh, Young-Ger,Cho, Hawon,Oh, Uhtaek,Kim, Hee-Doo,Joo, Yung Hyup,Shin, Song Seok,Kim, Jin Kwan,Jeong, Yeon Su,Koh, Hyun-Ju,Park, Young-Ho,Jew, Sang-Sup
, p. 631 - 634 (2005)
Seventeen biarylcarboxybenzamide derivatives were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor (VR1) in rat DRG neurons. The replacement of the piperazine moiety of the lead compound 1 with phenyl ring showed quite enhanced antagonistic activity. Among the prepared derivatives, N-(4-tert-butylphenyl)-4-pyridine-2-yl-benzamide (2, IC 50 = 31 nM) and N-(4-tert-butylphenyl)-4-(3-methylpyridine-2-yl) benzamide (3g, IC50 = 31 nM), showed 5-fold higher antagonistic activity than 1 in 45Ca2+-influx assay.
Synthesis, crystal structures and catalytic activity of three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with N-heterocyclic carbenes (NHCs) and triphenylphosphine
Xu, Chen,Li, Hong-Mei,Wang, Zhi-Qiang,Fu, Wei-Jun
, p. 11 - 15 (2014)
Three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with NHCs and PPh3 1-3 have been synthesized and characterized by elemental analysis, IR, NMR and single-crystal X-ray diffraction. Their application to Suzuki coupling of phenylboro
A general catalyst for Suzuki-Miyaura and Sonogashira reactions of aryl and heteroaryl chlorides in water
Peng, Hui,Chen, Ya-Qin,Mao, Shu-Lan,Pi, Yun-Xiao,Chen, You,Lian, Ze-Yu,Meng, Tong,Liu, Sheng-Hua,Yu, Guang-Ao
supporting information, p. 6944 - 6952 (2014/09/29)
We report the synthesis of 2-(3-sulfonatomesityl)-5-sulfonatoindenyl) dicyclohexylphosphine hydrate sodium salt and its use in palladium-catalyzed Suzuki-Miyaura and Sonogashira coupling reactions in water (and biphasic water-organic solvent mixtures) to prepare a variety of functionalized biaryls and aryl alkynes in excellent yield. This journal is the Partner Organisations 2014.
Synthesis, crystal structures and catalytic activity of three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with N-heterocyclic carbenes (NHCs) and triphenylphosphine
Xu, Chen,Li, Hong-Mei,Wang, Zhi-Qiang,Fu, Wei-Jun
, p. 11 - 15 (2014/12/11)
Three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with NHCs and PPh3 1-3 have been synthesized and characterized by elemental analysis, IR, NMR and single-crystal X-ray diffraction. Their application to Suzuki coupling of phenylboronic acid co
Synthesis, crystal structures and catalytic activity of three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with N-heterocyclic carbenes (NHCs) and triphenylphosphine
Xu, Chen,Li, Hong-Mei,Wang, Zhi-Qiang,Fu, Wei-Jun
, p. 11 - 15 (2015/02/19)
Three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with NHCs and PPh31-3 have been synthesized and characterized by elemental analysis, IR, NMR and single-crystal X-ray diffraction. Their application to Suzuki coupling of phenylboron
11,12-Cyclic thiocarbamate macrolide antibacterial agents
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Page/Page column 29-30, (2010/02/14)
The present invention is directed to novel macrolide antibacterial agents and processes for preparing them. The present invention is further directed to pharmaceutical compositions containing the novel macrolide antibacterial agents disclosed herein and t
Methods of treatment using an EP2 selective receptor agonist
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Page/Page column 48, (2010/02/13)
The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, facilitating the growth of tooth enamel or finger or toe nails, treating glaucoma, treating ocular hypertension, and repairing damage caused by metastatic bone disease using an EP2 selective receptor agonist.
3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents
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Page/Page column 61, (2010/02/05)
3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents of the formula: wherein R1, W, R3, R4, R5, R6, X, X′, and Z are as described herein and in which the substituents have th
6-O-acyl ketolide antibacterials
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, (2008/06/13)
6-O-Acyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, W, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
Method for treating glaucoma
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, (2008/06/13)
Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.