127406-08-0

Basic information

• Product Name: 4-PYRAZIN-2-YLBENZALDEHYDE
• Synonyms: 4-(2-PYRAZINYL)BENZENECARBALDEHYDE;4-PYRAZIN-2-YLBENZALDEHYDE;4-(Pyrazin-2-yl)benzenecarboxaldehyde
• CAS NO: 127406-08-0
• Molecular Formula: C₁₁H₈N₂O
• Molecular Weight: 184.19
• EINECS: 604-604-1
• Mol File: 127406-08-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 84-87°
• Boiling Point: 347.2±32.0 °C(Predicted)
• Appearance: /
• Density: 1.205±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.23±0.10(Predicted)
• CAS DataBase Reference: 4-PYRAZIN-2-YLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRAZIN-2-YLBENZALDEHYDE(127406-08-0)
• EPA Substance Registry System: 4-PYRAZIN-2-YLBENZALDEHYDE(127406-08-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 127406-08-0(Hazardous Substances Data)

Usage

General Description

4-Pyrazin-2-ylbenzaldehyde is a chemical compound with the formula C11H8N2O. It's commonly used in the synthesis of various pharmaceuticals and other organic compounds. It is aroma compound that emits a herbal-sweet-strong creamy odor. Its derivative, Phenylhydrazone, is used for the practice of chemosensing ensemble for the detection of nerve gases and pesticides. It may pose hazards if improperly handled or used, and appropriate safety measures should be followed. It is not a natural compound and does not naturally occur in the environment.

Upstream product

• 4009-98-7 (methoxymethyl)triphenylphosphonium chloride 
• 14508-49-7 2-chloropyrazin 
• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 87199-17-5 4-formylphenylboronic acid, 

Downstream Products

• 868856-13-7 C₁₅H₁₄N₂O₂ 
• 216060-23-0 4-(pyrazin-2-yl)benzoic acid 

Relevant articles and documents

Biarylcarboxybenzamide derivatives as potent vanilloid receptor (VR1) antagonistic ligands

Seventeen biarylcarboxybenzamide derivatives were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor (VR1) in rat DRG neurons. The replacement of the piperazine moiety of the lead compound 1 with phenyl ring showed quite enhanced antagonistic activity. Among the prepared derivatives, N-(4-tert-butylphenyl)-4-pyridine-2-yl-benzamide (2, IC 50 = 31 nM) and N-(4-tert-butylphenyl)-4-(3-methylpyridine-2-yl) benzamide (3g, IC50 = 31 nM), showed 5-fold higher antagonistic activity than 1 in 45Ca2+-influx assay.

Synthesis, crystal structures and catalytic activity of three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with N-heterocyclic carbenes (NHCs) and triphenylphosphine

Three cyclopalladated 6-bromo-2-ferrocenylquinoline complexes with NHCs and PPh3 1-3 have been synthesized and characterized by elemental analysis, IR, NMR and single-crystal X-ray diffraction. Their application to Suzuki coupling of phenylboronic acid co

A general catalyst for Suzuki-Miyaura and Sonogashira reactions of aryl and heteroaryl chlorides in water

We report the synthesis of 2-(3-sulfonatomesityl)-5-sulfonatoindenyl) dicyclohexylphosphine hydrate sodium salt and its use in palladium-catalyzed Suzuki-Miyaura and Sonogashira coupling reactions in water (and biphasic water-organic solvent mixtures) to prepare a variety of functionalized biaryls and aryl alkynes in excellent yield. This journal is the Partner Organisations 2014.