127472-35-9Relevant academic research and scientific papers
Cyclizations of substituted benzylidene-3-alkenylamines: Synthesis of the tricyclic core of the martinellines
Frank, Kristine E.,Aube, Jeffrey
, p. 655 - 666 (2007/10/03)
The martinellines (1 and 2) are natural products that possess both interesting biological activity and chemical structure. During the investigation of a hetero Diels-Alder route to these molecules, alternate Lewis acid-dependent cyclizations of (2'-amino-N'-tert-butoxycarbonyl-5'- chlorobenzylidene)-3-butenylamine (10) were observed. The reaction of a variety of imines with TMSOTf or TiCl4 led to the formation of different heterocycles including iminodibenzo[b,f][1,5]diazocines, hexahydropyrido[1,2- c]quinazolin-6-ones, tetrahydropyrrolo[1,2-c]quinazolin-5-ones, 2- arylpiperidines, and 2-arylpyrrolidines. Tetrahydropyrrolo[1,2-c]quinazolin- 5-one 54, obtained via this new methodology, was used as an intermediate in the synthesis of the tricyclic ring system (65) of the martinellines.
A General Approach to the Synthesis of 1,6-, 1,7-, and 1,8-Naphthyridines
Turner, James A.
, p. 4744 - 4750 (2007/10/02)
A new three-step procedure for pyridine annulation is described and illustrated with efficient syntheses of various 1,6-, 1,7-, and 1,8-naphthyridin-2-ones as well as 6-chloroquinolin-2-one.The regiospecific ortho metalation and subsequent formylation of
