1274754-67-4Relevant articles and documents
Fmoc-based synthesis of peptide thioesters for native chemical ligation employing a tert -butyl thiol linker
Raz, Richard,Rademann, Joerg
, p. 1606 - 1609 (2011/05/12)
tert-Butyl thioesters display an astonishing stability toward secondary amines in basic milieu, in contrast to other alkyl and aryl thioesters. Exploiting this enhanced stability, peptide thioesters were synthesized in a direct manner, applying a tert-butyl thiol linker for Fmoc-based solid-phase peptide synthesis.