1274754-75-4

Upstream product

• 76-83-5 trityl chloride 
• 763-89-3 4-methylpent-3-en-1-ol 
• 1274754-80-1 S-[1,1-dimethyl-4-(trityloxy)butyl] ethanethioate 
• 1274754-74-3 S-(4-hydroxy-1,1-dimethylbutyl) ethanethioate 
• 1274754-73-2 S-(4-{[(9H-fluoren-9-ylmethoxy)carbonyl]oxy}-1,1-dimethylbutyl) ethanethioate 
• 1274754-77-6 9H-fluoren-9ylmethyl 4-methylpent-3-enyl carbonate 

Downstream Products

• 1274754-68-5 S-[1,1-dimethyl-4-(trityloxy)butyl] 2-{[tert-butoxycarbonyl]amino}ethanethioate 
• 1274754-67-4 S-[1,1-dimethyl-4-(trityloxy)butyl] (2S)-2-{[tert-butoxycarbonyl]amino}-3-phenylpropanethioate 

Relevant academic research and scientific papers

Fmoc-based synthesis of peptide thioesters for native chemical ligation employing a tert -butyl thiol linker

tert-Butyl thioesters display an astonishing stability toward secondary amines in basic milieu, in contrast to other alkyl and aryl thioesters. Exploiting this enhanced stability, peptide thioesters were synthesized in a direct manner, applying a tert-butyl thiol linker for Fmoc-based solid-phase peptide synthesis.