127477-34-3

Upstream product

• 56456-85-0 1,4-Dihydro-1-phenyl-indeno[1,2-c]pyrazole-3-carboxylic acid,ethyl ester 
• 56457-23-9 1-phenyl-1,4-dihydro-1H-indeno[1,2-c]pyrazole-3-carboxylic acid 

Downstream Products

• 127477-03-6 2-cyano-3-(1,4-dihydro-1-phenyl-indeno[1,2-c]pyrazol-3-yl)-3-oxo-N-phenyl-propanamide 

Relevant academic research and scientific papers

Synthesis, central and peripheral benzodiazepine receptor affinity of pyrazole and pyrazole-containing polycyclic derivatives

A series of new pyrazole-condensed 6,5,5 tricyclic compounds were synthesized and tested to evaluate their binding affinities at both central (CBR) and peripheral (PBR) benzodiazepine receptors. Some 1-aryl-5- phenylpyrazole derivatives were also prepared and tested for comparison with their corresponding rigid tricyclic analogs. Among the newly synthesized 1-aryl-1,4-dihydro-indeno[1,2-c]pyrazoles bearing both an ethoxycarbonyl group at position 3 and a carbonyl function at the position 4, compound 4b emerged as a new potent (IC50 = 26.4 nM) and selective CBR ligand. The 4-oxo-1-aryl-1,4-dihydro-indeno[1,2-c]pyrazole diethylamide derivative 14a was instead identified as a relatively potent (IC50 = 124 nM) but highly selective PBR ligand.

Condensed pyrazole 3-oxo-propanenitrile derivatives

Condensed pyrazole 3-oxo-propanenitrile derivatives of formula (I) STR1 wherein X represents a --CH(R4)-- group, an oxygen atom or a --S(O)n -- group where n is 0, 1 or 2; R1 represents C1 -C6 alkyl,