56457-23-9

Upstream product

• 100-63-0 phenylhydrazine 
• 56456-85-0 1,4-Dihydro-1-phenyl-indeno[1,2-c]pyrazole-3-carboxylic acid,ethyl ester 
• 83-33-0 inden-1-one 
• 100397-38-4 ethyl β-(1-oxo-2,3-dihydro-1H-inden-2-yl)-α-oxoacetate 
• 10277-36-8 (1-oxo-indan-2-yl)-glyoxylic acid 

Downstream Products

• 127477-34-3 1,4-dihydro-1-phenyl-indeno[1,2-c]pyrazole-3-carbonyl chloride 

Relevant academic research and scientific papers

Synthesis, central and peripheral benzodiazepine receptor affinity of pyrazole and pyrazole-containing polycyclic derivatives

A series of new pyrazole-condensed 6,5,5 tricyclic compounds were synthesized and tested to evaluate their binding affinities at both central (CBR) and peripheral (PBR) benzodiazepine receptors. Some 1-aryl-5- phenylpyrazole derivatives were also prepared and tested for comparison with their corresponding rigid tricyclic analogs. Among the newly synthesized 1-aryl-1,4-dihydro-indeno[1,2-c]pyrazoles bearing both an ethoxycarbonyl group at position 3 and a carbonyl function at the position 4, compound 4b emerged as a new potent (IC50 = 26.4 nM) and selective CBR ligand. The 4-oxo-1-aryl-1,4-dihydro-indeno[1,2-c]pyrazole diethylamide derivative 14a was instead identified as a relatively potent (IC50 = 124 nM) but highly selective PBR ligand.

Chromophore-modified bis-benzo[g]indole carboxamides: Synthesis and antiproliferative activity of bis-benzo[g]indazole-3-carboxamides and related dimers

Tricyclic pyrazole dimers that comprise two kinds of CONH-(CH 2)n-N(CH3)-(CH2)n-NHCO bridges to which are linked potential DNA-intercalating groups such as 1H-benzo[g]indazole, 2H-benzo[g]indazole and

Condensed pyrazole 3-oxo-propanenitrile derivatives

Condensed pyrazole 3-oxo-propanenitrile derivatives of formula (I) STR1 wherein X represents a --CH(R4)-- group, an oxygen atom or a --S(O)n -- group where n is 0, 1 or 2; R1 represents C1 -C6 alkyl,

Esters and amides of 4,5-dihydrobenz[g]indazole-3-carboxylic acids and related compounds

Aminoalkyl esters and amides of 4,5-dihydrobenz[g]indazole-3-carboxylic acids and related compounds are described herein. They are useful as anti-ulcer agents, anti-arrhythmic agents, anti-bacterial agents, anti-protozoal agents, anthelmintics, anti-fungal agents, anti-algal agents and anti-inflammatory agents. The compounds are prepared from the appropriate carboxylic acid, alkyl ester, or acid chloride.