127485-48-7

Basic information

• Product Name: 1H-Indole-1-carbonyl chloride (9CI)
• Synonyms: 1H-Indole-1-carbonyl chloride (9CI);indolecarboxylic acid chloride
• CAS NO: 127485-48-7
• Molecular Formula: C₉H₆ClNO
• Molecular Weight: 179.60304
• Product Categories: ACIDHALIDE
• Mol File: 127485-48-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 318.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Indole-1-carbonyl chloride (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-1-carbonyl chloride (9CI)(127485-48-7)
• EPA Substance Registry System: 1H-Indole-1-carbonyl chloride (9CI)(127485-48-7)

Safety Data

• Hazardous Substances Data: 127485-48-7(Hazardous Substances Data)

Usage

Derivative of

Indole

Class

Indolecarboxylic acid derivatives

Physical state

Colorless to light yellow liquid at room temperature

Usage

Chemical intermediate in the synthesis of pharmaceuticals and agrochemicals

Reactivity

Versatile reagent for various organic reactions, including the preparation of indole derivatives with potential biological activity

Hazards

Harmful if inhaled, swallowed, or absorbed through the skin, and can cause irritation to the eyes and skin

Safety measures

Handle with caution and take proper safety measures.

Upstream product

• 120-72-9 indole 
• 13884-13-4 indole-1-carboxylic acid 

Downstream Products

• 1604061-30-4 N-(4-(N-(2,2,2-trifluoroethyl)sulfamoyl)-[1,1'-biphenyl]-2-yl)-1H-indole-1-carboxamide 
• 1588773-32-3 1,2-bis(4-bromophenyl)-3H-pyrrolo[1,2-a]indol-3-one 
• 103681-64-7 1,2-Diphenyl-3-oxo-3H-pyrrolo<1,2-a>indol 
• 1057237-65-6 1-ethyl-2-phenyl-3H-pyrrolo[1,2-a]indol-3-one 
• 1057237-56-5 1-methyl-2-phenyl-3H-pyrrolo[1,2-a]indol-3-one 

Relevant articles and documents

Polycyclic Indoline Derivatives by Dearomatizing Anionic Cyclization of Indole and Tryptamine-Derived Ureas

The base-promoted dearomatizing cyclization of anionic indole-containing urea derivatives provided tri- or tetracyclic indoline-containing scaffolds from lithiated urea intermediates. 3-Substituted indoles, including tryptamine derivatives, generally underwent the reaction in high yield and with excellent diastereoselectivity. In situ IR spectroscopy suggests a deprotonation-carbolithiation-reprotonation mechanism.

Ruthenium(II)-Catalyzed Regio- and Stereoselective C-H Allylation of Indoles with Allyl Alcohols

A ruthenium-catalyzed C-H allylation of indoles with allyl alcohols via β-hydroxide elimination is reported. Without external oxidants and expensive additives, this reaction features mild reaction conditions, compatibility with various functional groups, and good to excellent regioselectivity and stereoselectivity.

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

Provided are aryl sulfonamide diarylurea derivative compounds that are inhibitors of mutant isocitrate dehydrogenase 1/2 (IDH 1/2), useful for treating cancer. Also provided are methods of treating cancer comprising administering to a subject in need thereof a compound described herein. Cancers that are treatable by the compounds of the invention are glioblastoma, myelodysplastic syndrome, myeloproliferative neoplasm, acute myelogenous leukemia, sarcoma, melanoma, non-small cell lung cancer, chondrosarcoma, and non-Hodgkin's lymphoma (NHL).