1274939-76-2Relevant academic research and scientific papers
Towards non-peptide ANG II AT1 receptor antagonists based on urocanic acid: Rational design, synthesis and biological evaluation
Agelis, George,Resvani, Amalia,Matsoukas, Minos-Timotheos,Tselios, Theodore,Kelaidonis, Konstantinos,Kalavrizioti, Dimitra,Vlahakos, Demetrios,Matsoukas, John
, p. 411 - 420 (2011)
A series of o-, m- and p-benzyl tetrazole derivatives 11a-c has been designed, synthesized and evaluated as potential Angiotensin II AT1 receptor antagonists, based on urocanic acid. Compound 11b with tetrazole moiety at the m-position showed moderate, however, higher activity compared to the o- and p-counterpart analogues. Molecular modelling techniques were performed in order to extract their putative bioactive conformations and explore their binding modes.
