Amino Acids p. 411 - 420 (2011)
Update date:2022-08-02
Topics:
Agelis, George
Resvani, Amalia
Matsoukas, Minos-Timotheos
Tselios, Theodore
Kelaidonis, Konstantinos
Kalavrizioti, Dimitra
Vlahakos, Demetrios
Matsoukas, John
A series of o-, m- and p-benzyl tetrazole derivatives 11a-c has been designed, synthesized and evaluated as potential Angiotensin II AT1 receptor antagonists, based on urocanic acid. Compound 11b with tetrazole moiety at the m-position showed moderate, however, higher activity compared to the o- and p-counterpart analogues. Molecular modelling techniques were performed in order to extract their putative bioactive conformations and explore their binding modes.
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