127499-97-2

Upstream product

• 826-41-5 N-Methyl-2,2-diethoxypyrrolidine 
• 64039-36-7 S-(4-nitrobenzyl)isothiourea hydrobromide 
• 105878-21-5 [1-Methyl-pyrrolidin-(2E)-ylidene]-thiourea 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Relevant academic research and scientific papers

Synthesis of 4-(ω-aminoalkyl)- or 4-(ω-lactamiminoalkyl)thiazoles by ring chain transformation of isothioureas with lactam derivatives

CH-Acidic isothioureas 1 react with lactam acetals 2 at the unsubstituted N-atom as well as at the acidic S-methylene group giving 4-(ω-aminoalkyl)thiazoles 6. The latter are further transformed to 4-(ω-lactamiminoalkyl)thiazoles 8, if lactim ethers 3 are used in reactions with isothioureas 1.