64039-36-7

Usage

Uses

Used in Pharmaceutical Research:
3-(4-nitrobenzyl)isothiourea HBr is used as a research compound for its potential vasodilatory effects, which are important in the study and development of treatments for cardiovascular diseases and hypertension.
Used in Antimicrobial Development:
3-(4-nitrobenzyl)isothiourea HBr is used as a starting material in the development of novel antimicrobial agents due to its demonstrated antifungal and antibacterial properties, indicating its potential in combating various microbial infections.
Used in Chemical Synthesis:
In the chemical industry, 3-(4-nitrobenzyl)isothiourea HBr may be used as an intermediate in the synthesis of other pharmaceuticals or chemical compounds, leveraging its unique structural features for the creation of new molecules with specific therapeutic or industrial applications.

InChI:InChI=1/C8H9N3O2S.BrH/c9-8(10)14-5-6-1-3-7(4-2-6)11(12)13;/h1-4H,5H2,(H3,9,10);1H

Upstream product

• 17356-08-0 thiourea 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 143602-37-3 5-(4-Nitro-phenyl)-4-{3-[pyrrolidin-(2E)-ylideneamino]-propyl}-thiazol-2-ylamine; hydrobromide 
• 127499-97-2 4-(3-Methylamino-propyl)-5-(4-nitro-phenyl)-thiazol-2-ylamine; hydrobromide 
• 99941-65-8 N-[5-4-methyl-(4-nitro-phenyl)-thiazol-2-yl]-acetamide 
• 99941-63-6 [5-(4-Nitro-phenyl)-thiazol-2-yl]-[1-pyrrolidin-1-yl-meth-(E)-ylidene]-amine 
• 99941-64-7 [1-Morpholin-4-yl-meth-(E)-ylidene]-[5-(4-nitro-phenyl)-thiazol-2-yl]-amine 
• 99941-62-5 N,N-Dimethyl-N'-[5-(4-nitro-phenyl)-thiazol-2-yl]-formamidine 
• 1151798-76-3 N,N-diethylureamido-2-(4-nitrobenzyl)-2-thiopseudourea 
• 4025-75-6 (4-nitrophenyl)methanesulfonyl chloride 
• 143602-38-4 2-Acetylamino-4-<5-(azepin-2-ylideneaminopentyl)>-5-(4-nitrophenyl)-1,3-thiazole hydrobromide 
• 99941-67-0 N-[5-(4-Nitro-phenyl)-4-phenyl-thiazol-2-yl]-benzamide 
• 99956-20-4 [3-[1-Dimethylamino-meth-(E)-ylidene]-2-(4-nitro-benzyl)-isothioureidomethylene]-dimethyl-ammonium; chloride 

Relevant academic research and scientific papers

Tert -Butyl Hypochlorite Mediated Oxidative Chlorination of S -Alkylisothiourea Salts: Synthesis of Sulfonyl Chlorides

Under neutral conditions, a variety of S-alkylisothiourea salts were smoothly converted into the corresponding sulfonyl chlorides through tert-butyl chlorite mediated oxidative chlorination in good to excellent yields after simple purification. In addition to the environmental and procedural advantages of this method, the neutral conditions potentially make it applicable to substrates that bear acid-sensitive functional groups. For example, the Cbz-protected 2-aminoethanesulfonyl chloride could be synthesized in moderate to good yields under the current neutral conditions, and the acid-sensitive Cbz-protecting group was not affected.

Clean and economic synthesis of alkanesulfonyl chlorides from S-alkyl isothiourea salts via bleach oxidative chlorosulfonation

A simple procedure for clean and economic synthesis of alkanesulfonyl chlorides via bleach-mediated oxidative chlorosulfonation of S-alkyl isothiourea salts is disclosed. This procedure is environment- and worker-friendly with the advantages of readily accessible materials and reagents, simple and safe operations, easy purification without chromatography, and affords high yields of up to 99%.

Simple synthesis of sulfonyl chlorides from thiol precursors and derivatives by NaClO2-mediated oxidative chlorosulfonation

A simple method to synthesize diverse sulfonyl chlorides through NaClO 2-mediated oxidative chlorosulfonation of S-alkyl isothiourea salts is presented. The approach features safe operation, environmental friendliness, convenient purification procedures, and delivers high yields of up to 96%. The procedure is also applicable to substrates such as thiols, disulfides, thioacetates, and xanthates. It is a versatile and convenient method for the synthesis of various sulfonyl chlorides from different thiol precursors and derivatives. Georg Thieme Verlag Stuttgart, New York.

PROCESSES AND INTERMEDIATES FOR PRODUCING AMINOBENZIMIDAZOLE UREAS

The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of bacterial gyrase and Topoisomerase IV (Topo IV).

SOLID FORMS OF 1-ETHYL-3-(5-(5-FLUOROPYRIDIN-3-YL)-7-(PYRIMIDIN-2-YL)-1H-BENZO[D]IMIDAZOL-2-YL)UREA

Solid forms of crystalline1-ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)- 1H-benzo[d]imidazol-2-yl)urea, compositions containing solid forms of crystalline 1- ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea and m