127501-08-0Relevant academic research and scientific papers
Diastereoselective electrophilic substitution of γ-oxy-substituted benzyllithiums
Arrica, Maria A,Azzena, Ugo,Pilo, Luciano,Piras, Elisabetta
, p. 5137 - 5139 (2002)
Reductive lithiation of diastereoisomeric mixtures of 4-aryl-5-methyl-1,3-dioxanes occurs with epimerization at the benzylic centre. Reaction of intermediate organometals with alkyl halides or CO2 afforded 2-methyl-3-substituted-3-phenylpropan-1-ols, or the corresponding lactones, with satisfactory yields and satisfactory to high diastereoselectivities. Observed diastereoselectivities strongly depend on the substitution pattern of starting materials.
DIANION-BASED METHODOLOGY FOR THE PREPARATION OF 2,3-DISUBSTITUTED BUTYROLACTONES
Belletire, John L.,Mahmoodi, Nosrat O.
, p. 3371 - 3378 (2007/10/02)
Unsymmetrical coupling utilizing the reaction of acylsulfonamide dianions with alpha-iodocarboxylate salts followed by a sequence consisting of selective reduction of the carboxylic acid group, hydrolysis of the acylsulfonamide, and spontaneous ring closure affords 2,3-disubstituted butyrolactones.
