1275088-21-5

Basic information

• Product Name: N-(2,4-dimethoxybenzyl)-6-fluoropyridin-2-amine
• Synonyms: N-(2,4-dimethoxybenzyl)-6-fluoropyridin-2-amine
• CAS NO: 1275088-21-5
• Molecular Weight: 262.284
• Mol File: 1275088-21-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(2,4-dimethoxybenzyl)-6-fluoropyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-dimethoxybenzyl)-6-fluoropyridin-2-amine(1275088-21-5)
• EPA Substance Registry System: N-(2,4-dimethoxybenzyl)-6-fluoropyridin-2-amine(1275088-21-5)

Safety Data

• Hazardous Substances Data: 1275088-21-5(Hazardous Substances Data)

Upstream product

• 1513-65-1 2,6-difluoro pyridine 
• 20781-20-8 2,4-Dimethoxybenzylamine 
• 1607485-74-4 N-(2,4-dimethoxybenzylidene)-6-fluoropyridin-2-amine 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 1597-32-6 6-fluoro-pyridin-2-ylamine 

Downstream Products

• 1607486-20-3 N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide 
• 1607486-21-4 (R)-N-(6-fluoropyridin-2-yl)-3-(1-(2-iodophenyl)ethyl)-5-methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide 
• 1607486-22-5 (R)-tert-butyl 4-(2-(1-(6-(N-(6-fluoropyridin-2-yl)sulfamoyl)-5-methyl-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1607485-76-6 (R)-tert-butyl 8-(1-(6-(N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)sulfamoyl)-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1607485-75-5 N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide 
• 1607485-79-9 N-(2,4-dimethoxybenzyl)-5-fluoro-N-(6-fluoropyridin-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide 
• 1607485-96-0 (R)-5-fluoro-N-(6-fluoropyridin-2-yl)-3-(1-(2-iodophenyl)ethyl)-2-oxo-2,3-dihydrobenzo[d]-oxazole-6-sulfonamide 
• 1607485-80-2 (R)-tert-butyl 8-(1-(6-(N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)sulfamoyl)-5-fluoro-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 

Relevant articles and documents

HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS

This invention is directed to heteroaryl-substituted sulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

COMPOUNDS

Provided are benzoxazolinone sulfonamide derivatives that inhibit Na v1.7 activity, pharmaceutical compositions containing them and their use in therapy for the treatment of diseases mediated by Na v1.7 activity.

BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS

Disclosed are compounds of Formula A: Formula A, or a salt thereof, wherein "Het", Ra, and Rb are defined herein, which have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating neuropathic pain disorders using the same.