127525-49-9

Usage

Chemical structure

A derivative of triazine and thione

Usage

Commonly used in the synthesis of organic compounds

Potential applications

Pharmaceutical and agrochemical industries

Significance

Identified as a potential scaffold for drug development

Structural features

Unique properties and structural features contribute to its potential in drug development

Investigated activities

Antimicrobial, antifungal, and antioxidant activities

Field of interest

Medicinal chemistry

Upstream product

• 40108-73-4 5-benzyl-3-phenyl-6-oxo-1,6-dihydro-1,2,4-triazine 

Downstream Products

• 227951-67-9 3,5-diphenyl-1-thia-4,6,7-triaza-indene 
• 871250-95-2 5-benzyl-3-phenyl-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazin-6(1H)-thione 
• 128009-61-0 Acetic acid (2R,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(5-benzyl-3-phenyl-6-thioxo-6H-[1,2,4]triazin-1-yl)-tetrahydro-pyran-3-yl ester 

Relevant academic research and scientific papers

Synthesis of some novel N-ribosyl-1,2,4-triazin-6(1H)-/ones or thiones as potential antibacterial and antifungal chemotherapeutics

Ribosylation of 3-aryl-5-benzyl(or substituted benzyl)-1,2,4-triazin-6(1H)- /ones or thiones with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose gave the corresponding 3-aryl-5-benzyl(or substituted benzyl)-1-(2,3,5-tri-O-benzoyl- β-D-ribofuranosyl)-1,2,4-triazin-6(1H)-/ones or thiones. The structure of the new ribosides was confirmed chemically and spectroscopically. Copyright

Gas-phase thermolysis of thieno[3,2-e][1,2,4]triazines. Interesting routes towards heterocyclic ring systems

Gas-phase thermolysis of thieno[3,2-e][1,2,4]triazines gave benzonitrile, isothiazole, pyrimidine, [1]benzothieno[2,3-d]pyrimidine and thieno[3,2-d]thiazole derivatives. A mechanism of these pyrolytic transformation was proposed. Two new and efficient syntheses of the starting thieno[3,2-e][1,2,4]triazines were reported.