127526-66-3

Basic information

• Product Name: 3,5-dichloro-L-tyrosine methyl ester
• Synonyms: 3,5-dichloro-L-tyrosine methyl ester
• CAS NO: 127526-66-3
• Molecular Weight: 264.108
• Mol File: 127526-66-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3,5-dichloro-L-tyrosine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dichloro-L-tyrosine methyl ester(127526-66-3)
• EPA Substance Registry System: 3,5-dichloro-L-tyrosine methyl ester(127526-66-3)

Safety Data

• Hazardous Substances Data: 127526-66-3(Hazardous Substances Data)

Upstream product

• 60-18-4 L-tyrosine 
• 3417-91-2 L-tyrosine methyl ester HCl 

Downstream Products

• 15106-62-4 (S)-2-amino-3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid 
• 67591-20-2 (S)-2-amino-3-(3,5-dichloro-4-methoxyphenyl)propanoic acid 
• 127526-61-8 (8R,11R,14S)-8-Amino-18,19-dichloro-11-(4-hydroxy-phenyl)-5-iodo-4-methoxy-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester; hydrobromide 
• 126782-53-4 (S)-2-[(R)-2-[(R)-2-Benzyloxycarbonylamino-2-(4-hydroxy-3,5-diiodo-phenyl)-acetylamino]-2-(4-benzyloxy-phenyl)-acetylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionic acid methyl ester 
• 126782-54-5 (11R,14S)-8-Benzyloxycarbonylamino-11-(4-benzyloxy-phenyl)-18,19-dichloro-4-hydroxy-5-iodo-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester 
• 127526-60-7 (S)-2-[(R)-2-Amino-2-(4-benzyloxy-phenyl)-acetylamino]-3-(3,5-dichloro-4-hydroxy-phenyl)-propionic acid methyl ester; hydrochloride 

Relevant articles and documents

Anti-parasite and cytotoxic activities of chloro and bromo L-tyrosine derivatives

A series of twenty-one L-tyrosine derivatives with modifications in the halogenation pattern of the aromatic ring and different degree of methylations on the amine and phenolic hydroxyl groups were synthesized. The structures of all the intermediates and target compounds were confirmed unambiguous by spectroscopy analysis. Additionally, all compounds were evaluated against Plasmodium falciparum and Leishmania panamensis parasites between 20-702 μg mL-1. The cytotoxic evaluation was done to determine the selectivity index for each compound. Six compounds had the lower EC50 (effective concentration 50) against L. panamensis. One of these compounds was the most active with an EC50 at 24.13 μg mL-1 (76.07 μM). All derivatives showed no significant activity against P. falciparum and no compound has in vitro antifungal activity at 500 μg mL-1.