67591-20-2

Basic information

• Product Name: L-Tyrosine, 3,5-dichloro-O-methyl-
• CAS NO: 67591-20-2
• Molecular Formula: C10H11Cl2NO3
• Molecular Weight: 264.108
• Mol File: 67591-20-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Tyrosine, 3,5-dichloro-O-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine, 3,5-dichloro-O-methyl-(67591-20-2)
• EPA Substance Registry System: L-Tyrosine, 3,5-dichloro-O-methyl-(67591-20-2)

Safety Data

• Hazardous Substances Data: 67591-20-2(Hazardous Substances Data)

Upstream product

• 3417-91-2 L-tyrosine methyl ester HCl 
• 60-18-4 L-tyrosine 
• 127526-66-3 3,5-dichloro-L-tyrosine methyl ester 
• 67591-19-9 N-Acetyl-o-methyl-3,5-dichloro-L-tyrosine methyl ester 

Downstream Products

• 67591-21-3 (S)-α-Bromo-β(3,5-dichloro-4-methoxyphenyl)-propionic Acid 
• 67591-22-4 N-Carbobenzyloxy-o-methyl-3,5-dichloro-D-tyrosine methyl ester 

Relevant articles and documents

Synthesis and trypanocide activity of chloro-l-tyrosine and bromo-l-tyrosine derivatives

Twenty-two halogenated l-tyrosine derivatives were synthesized to examine new substances for the treatment of Chagas disease. The synthesis of these derivatives with different degree of substitution in the amino group with methyl iodide, giving primary, tertiary, and quaternary amino acids. All compounds were tested in vitro against intracellular amastigotes of Trypanosoma cruzi, and the cytotoxicity were evaluated over monocytic cell line U-937. Compound 25 was the most active against T. cruzi with a EC50 of 75.52 μM compared with benznidazole with a EC50 of 58.79 μM. Compounds 3, 4, 7, and 15 were the derivatives with the best selectivity index (SI) with values of 7.5, 8.3,12.1, and 8.6, respectively. Finally, compound 7 was the safer and the more promising derivative against T. cruzi.