127531-40-2

Upstream product

• 127531-39-9 4,5-bisbenzyloxy-2-methylbenzoic acid 
• 18863-72-4 4-bromo-5-methylbenzene-1,2-diol 
• 452-86-8 4-methyl-1,2-dihydroxybenzene 
• 4790-00-5 3,4-dibenzyloxytoluene 
• 20736-28-1 4,5-dimethoxy-2-methylbenzoic acid 

Relevant academic research and scientific papers

A 4, 5 - dihydroxy -2 - methyl benzoic acid

The invention discloses a preparation method of 4,5-dihydroxyl-2-methyl benzoic acid and belongs to the fields of fine chemical engineering and medicine intermediates. The preparation method of 4,5-dihydroxyl-2-methyl benzoic acid comprises the following steps: preparing an intermediate III or V by taking 4-methylbenze-1,2-diphenol as a raw material, then preparing an intermediate IV by virtue of the intermediate III or V, then transforming the intermediate IV into an intermediate II, and finally preparing 4,5-dihydroxyl-2-methyl benzoic acid by virtue of the intermediate II. The preparation method of 4,5-dihydroxyl-2-methyl benzoic acid has the advantage that the problems that raw materials are difficult to acquire, byproducts are many, yield is low, cost is high, steps are miscellaneous, safety can not be guaranteed and serious pollution is produced in the prior art are overcome.

Studies on the structure and biosynthesis of tridentoquinone and related meroterpenoids from the mushroom Suillus tridentinus (Boletales)

Tridentoquinone (1), the main pigment of Suillus tridentinus, is accompanied by the known meroterpenoid bolegrevilol (3) and a dimer, tridentorubin (5). The absolute configuration of 1 was unambiguously established by a single-crystal X-ray analysis of the corresponding (-)-camphanoate. The structure of 5 was elucidated by 2D NMR techniques including a 2D INADEQUATE experiment. Feeding experiments with [1-13C]-labeled 4-hydroxybenzoic acid (6*) and 3,4-dihydroxybenzoic acid (7*) proved the incorporation of these precursors into all three metabolites. Tridentoquinone (1) was monolabeled at C-1 suggesting the formation of the ansa ring by oxidative cyclisation of 2-geranylgeranyl-6-hydroxybenzoquinone (10). This was supported by the isolation of the expected intermediate, deoxytridentoquinone (11), from the mushroom extract. Tridentorubin (5) may be formed by addition of precursor 10 to tridentoquinone (1). This hypothesis is backed up by the in vitro formation of an analogous product 13 from 1 and 1,4-benzoquinone. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.