127560-66-1

Basic information

• Product Name: N-Ethyl-N-(2,2-difluoro-1-methoxyethyl)aniline
• Synonyms: N-Ethyl-N-(2,2-difluoro-1-methoxyethyl)aniline
• CAS NO: 127560-66-1
• Molecular Weight: 215.243
• Mol File: 127560-66-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-Ethyl-N-(2,2-difluoro-1-methoxyethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-Ethyl-N-(2,2-difluoro-1-methoxyethyl)aniline(127560-66-1)
• EPA Substance Registry System: N-Ethyl-N-(2,2-difluoro-1-methoxyethyl)aniline(127560-66-1)

Safety Data

• Hazardous Substances Data: 127560-66-1(Hazardous Substances Data)

Upstream product

• 155094-61-4 N-Ethyl-N-phenyldifluoroacetamide 
• 54962-15-1 lithium N-ethyl-N-phenylamide 
• 67-56-1 methanol 
• 137607-97-7 N-(2,2-Difluoroethyl)-N-ethylaniline 

Relevant articles and documents

Electrolytic Reactions of Fluoroorganic Compounds. 14. Regioselective Anodic Methoxylation of N-(Fluoroethyl)amines. Preparation of Highly Useful Fluoroalkylated Building Blocks

Anodic methoxylation of various types of N-(fluoroethyl)amines, ArRNCH2Rf (Rf = CF3, CHF2, CH2F, etc.) has been systematically studied and it was found that a methoxy group was exclusively or preferentially introduced into the position α to the fluoromethyl (Rf) group, depending on the Rf and R groups.The effect of the Rf group on the promotion of the anodic α-methoxylation decreased in the order CF3, CHF2, and CH2F.This remarkable promotion effect and unique regioselectivity can be explained mainly in terms of the α-CH kinetic acidities of the cation radicals formed by one-electron oxidation of the amines.The α-methoxylated products are highly useful precursors for the construction of carbon-carbon bonds α to the trifluoromethyl and difluoromethyl groups, which is difficult by other methods.