127568-36-9Relevant academic research and scientific papers
Chiral Carboxylic Acid Enabled Achiral Rhodium(III)-Catalyzed Enantioselective C?H Functionalization
Lin, Luqing,Fukagawa, Seiya,Sekine, Daichi,Tomita, Eiki,Yoshino, Tatsuhiko,Matsunaga, Shigeki
supporting information, p. 12048 - 12052 (2018/09/11)
Reported is an achiral CpxRhIII/chiral carboxylic acid catalyzed asymmetric C?H alkylation of diarylmethanamines with a diazomalonate, followed by cyclization and decarboxylation to afford 1,4-dihydroisoquinolin-3(2H)-one. Secondary
A cation-directed two-component cascade approach to enantioenriched pyrroloindolines
Wolstenhulme, Jamie R.,Cavell, Alex,Grediak, Matija,Driver, Russell W.,Smith, Martin D.
supporting information, p. 13585 - 13588 (2015/02/19)
A cascade approach to complex pyrroloindolines bearing all-carbon quaternary stereocentres has been developed. This two-component process uses a chiral ammonium salt to control diastereo- and enantioselectivity in the addition of isocyanides to functionalized alkenes to afford pyrroloindolines with up to three stereocentres. A mechanistic proposal involving intramolecular hydrogen bond activation of the isocyanide is described.
METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N (1-BENZHYDRYLAZETIDIN-3-YL)-N-PHENYLMETHYLSULFONAMIDE
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Page/Page column 7, (2008/06/13)
The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide.
UREAS IN ORGANIC SYNTHESIS. V. REACTIONS OF AROMATIC KETONES AND 1,2-DIKETONES WITH UREAS IN FORMIC ACID
Bakibaev, A.A.,Yagovkin, A.Yu.,Filimonov, V.D.
, p. 1326 - 1331 (2007/10/02)
Urea in formic acid is a general and practical reagent for the reductive aminoformylation of benzophenones and fluoren-9-one in the synthesis of N-diarylmethylformamides, which exhibit antispasmodic activity.With benzophenone in formic acid 1,3-dimethylurea gives a high yield of N-methyl-N-benzhydrylformamide.Urea reacts selectively with benzil and benzoin, forming both the bicyclic bisurea and monocyclic nitrogen-containing heterocycles, depending on the temperature.It was proposed for the first time to use arylmethylenebisureas as reagents in reaction with benzil for the production of 1,5-diphenyl-2,4,6,8-tetraazabicyclooctane-3,7-dione or 2,4,5-triphenylimidazole.
