14212-38-5

Upstream product

• 1714-50-7 4,4'-dichlorobenzophenone oxime 
• 77287-34-4 formamide 
• 90-98-2 4,4'-Dichlorobenzophenone 
• 127568-36-9 N-(bis(4-chlorophenyl)methyl)formamide 
• 623-03-0 4-Cyanochlorobenzene 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 90-97-1 4,4'-dichlorobenzophenone 

Downstream Products

• 19495-07-9 di-p-chlorobenzhydrylisothiocyanate 
• 1101850-30-9 (S)-N-{(R)-2-[bis(p-chlorophenyl)methylamino]-2-phenylethyl}prolinol 
• 1350710-39-2 4-[(1R,3R,4R)-4-{[bis(4-chlorophenyl)methyl]carbamoyl}-3-(4-bromophenyl)cyclohexyl]morpholine 
• 144267-37-8 4,4-di-p-chlorophenyl-1-palmitoyloxy-imidazolidine-2,5-dithione 
• 144267-50-5 4,4-di-p-chlorophenyl-5-n-pentadecylthio-2,3-(4H)-dihydroimidazole-2-thione 
• 144267-32-3 1-hydroxy-4,4-di-p-chlorophenylimidazolidine-2,5-dithione 
• 144267-27-6 4,4-di-p-chlorophenylthiazolidine-2,5-dithione 
• 1026361-55-6 (1S,3aS,3bS,9aR,9bS,11aS)-1-{[Bis-(4-chloro-phenyl)-methyl]-carbamoyl}-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,7,8,9,9a,9b,10,11,11a-tetradecahydro-cyclopenta[i]phenanthridine-5-carboxylic acid tert-butyl ester 
• 103035-65-0 N,N'-bis-(4,4'-dichloro-benzhydryl)-thiourea 

Relevant academic research and scientific papers

Chiral Carboxylic Acid Enabled Achiral Rhodium(III)-Catalyzed Enantioselective C?H Functionalization

Reported is an achiral CpxRhIII/chiral carboxylic acid catalyzed asymmetric C?H alkylation of diarylmethanamines with a diazomalonate, followed by cyclization and decarboxylation to afford 1,4-dihydroisoquinolin-3(2H)-one. Secondary

Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors

The synthesis, SAR, binding affinities and pharmacokinetic profiles are described for a series of cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors discovered by high throughput screening. Compounds show high levels of ex vivo target engagement in mouse plasma 20 h post oral dose.

METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N (1-BENZHYDRYLAZETIDIN-3-YL)-N-PHENYLMETHYLSULFONAMIDE

The invention relates to a novel method for the synthesis of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulfonamide.

NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS

This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy an

A practical synthesis of para di- and mono-substituted benzhydrylamines from benzhydrol precursors

A series of para-substituted benzhydrylamines 6 were obtained by substitution of the corresponding benzhydrol precursors 1 with phenyl carbamate 2 under acidic conditions, followed by basic hydrolysis of the carbamate intermediates 3. One unsymmetrical intermediate 3i has been resolved by preparative chiral chromatography. Subsequent deprotection of the carbamate function led to the recovery of enantiomerically pure (+)- and (-)- 4-chlorobenzhydryl amines.

Substituted benzhydryl lactamimide derivatives

Novel compounds useful as diuretic agents and anticoagulants are represented by the following formula SPC1 Wherein m is a positive whole integer of from 1 to 3; n is a positive whole integer of from 3 to 7; R and R1 may be the same or different