127568-43-8

Basic information

• Product Name: N-benzhydryl-3,4-dimethoxybenzamide
• Synonyms: N-benzhydryl-3,4-dimethoxybenzamide;N-(diphenylmethyl)-3,4-dimethoxybenzamide
• CAS NO: 127568-43-8
• Molecular Formula: C₂₂H₂₁NO₃
• Molecular Weight: 347.40704
• Mol File: 127568-43-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-benzhydryl-3,4-dimethoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzhydryl-3,4-dimethoxybenzamide(127568-43-8)
• EPA Substance Registry System: N-benzhydryl-3,4-dimethoxybenzamide(127568-43-8)

Safety Data

• Hazardous Substances Data: 127568-43-8(Hazardous Substances Data)

Upstream product

• 91-00-9 Benzhydrylamine 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 91-01-0 1,1-Diphenylmethanol 
• 2024-83-1 veratronitrile 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Relevant articles and documents

Practical Synthesis of N -(Diphenylmethyl)- and N -(1-Adamantyl)amides Directly from Aldehydes via a One-Pot Schmidt and Ritter Reaction Sequence

Nonoxidative and noncoupling reaction conditions have been developed for the synthesis of N-(diphenylmethyl)- and N-(1-adamantyl)amide derivatives directly from aldehydes by employing the concept of a Schmidt and Ritter reaction sequence in a one-pot operation. The reagent mixture consisting of sodium azide and HBF4·OEt2 in acetic acid converts the aldehydes into their respective nitrile analogues which in situ undergo the Ritter reaction with diphenylmethanol or 1-adamantanol to afford the corresponding N-(diphenylmethyl)- or N-(1-adamantyl)amide derivatives in very good yields. The method does not require column chromatographic purification for isolation of the products. With its simple reaction procedure and easy product purification technique, this method outshines earlier conventional two-step methods.