12758-40-6

Basic information

• Product Name: Carboxyethylgermanium sesquioxide
• Synonyms: ORGANIC GERMANIUM;CARBOXYETHYLGERMANIUM SESQUIOXIDE;BIS(CARBOXYETHYLGERMANIUM SESQUIOXIDE);BIS-BETA CARBOXYETHYLGERMANIUM SESQUIOXIDE;BETA-CARBOXYETHYLGERMANIUM OXIDE;BETA-CARBOXYETHYLGERMANIUM SESQUIOXIDE;BIS[2-CARBOXYETHYLGERMANIUM(IV)] SESQUIOXIDE;BIS(2-CARBOXYETHYLGERMANIUM SESQUIOXIDE)
• CAS NO: 12758-40-6
• Molecular Formula: C₆H₁₀Ge₂O₇
• Molecular Weight: 339.42
• EINECS: 235-800-0
• Product Categories: Ge (Germanium) Compounds;Classes of Metal Compounds;Semimetal Compounds;Nutritional Supplements
• Mol File: 12758-40-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 320°C
• Appearance: white powder
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Aqueous Base (Sparingly)
• PKA: 3.6(at 25℃)
• Water Solubility: Slightly soluble in water.
• Merck: 14,7795
• CAS DataBase Reference: Carboxyethylgermanium sesquioxide(CAS DataBase Reference)
• NIST Chemistry Reference: Carboxyethylgermanium sesquioxide(12758-40-6)
• EPA Substance Registry System: Carboxyethylgermanium sesquioxide(12758-40-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 2
• RTECS: UA2459750
• TSCA: Yes
• Hazardous Substances Data: 12758-40-6(Hazardous Substances Data)

Usage

Description

Propagermanium, the first organogermanium compound marketed as a pharmaceutical, is indicated for the oral treatment of chronic hepatitis B. Propagermanium is reported to enhance production of interferon α/β in virus infected mice and in human peripheral blood mononuclear cells but does not inhibit the growth of various DNA or RNA viruses in vitro. Therefore, enhancement of the host immune system against virus infection was proposed to be responsible for its antiviral activity. Propagermanium also exhibits potent antitumor activity, reportedly via stimulation of T lymphocytes to produce a lyrnphokine (s), possibly interferon-y, which induces the generation and activation of cytotoxic macrophages leading to elimination of tumor cells. Propagermanium has been reported to regulate calcium metabolism and to alleviate cancerous pain and osteocope.

Originator

Sanwa Kagaku (Japan)

Uses

Different sources of media describe the Uses of 12758-40-6 differently. You can refer to the following data:
1. A bifunctional metalloligand with metal-C (Ge-C) bonds,bis(carboxyethylgermanium) sesquioxide, has been used to make two metal-organometallic frameworks (MOMFs). bis-(carboxyethylgermanium)sesquioxide is a as a promising anti-oxidative agent. Bis(carboxyethylgermanium) sesquioxide induce INF-γ and has undergone clinical trials with promising preclinical results.
2. Bis(2-carboxyethylgermanium(IV) sesquioxide) can be used as a precursor in the preparation of photoluminescent carbon dots, applicable as fluorescent probes in bioimaging applications.
3. antifungal and antiseptic

Brand name

Serosion

General Description

Bis(2-carboxyethylgermanium(IV) sesquioxide), also known as repagermanium, is a water-soluble organogermanium compound that exhibits immunostimulatory properties. It is also used as an ingredient in food and cosmetics.

Safety Profile

Moderately toxic by intravenous route. Experimental reproductive effects. See also GERMANIUM COMPOUNDS.

InChI:InChI=1/C6H10Ge2O7/c1-5(14-13)4-8(12)15-7(11)3-2-6(9)10/h13H,1-4H2,(H,9,10)

Synthetic route

sodium [99Tc]pertechnetate + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → (99m)Tc-labeled bis-carboxyethylgermanium sesquioxide

Conditions	Yield
With hydrogenchloride; sodium chloride; tin(ll) chloride In water at 20℃; for 0.5h; pH=4;	99%

samarium(III) oxide + 1,10-Phenanthroline (66-71-7) + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → [Sm8(1,10-phenanthroline)2Ge12(μ3-O)24(CH2CH2COO-)12(H2O)16]*2(1,10-phenanthroline)*16H2O

Conditions	Yield
With hydrogenchloride at 150℃; for 168h; pH=2; Autoclave;	86%

1,10-Phenanthroline (66-71-7) + europium(III) oxide + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → [Eu8(1,10-phenanthroline)2Ge12(μ3-O)24(CH2CH2COO-)12(H2O)16]*2(1,10-phenanthroline)*16H2O

Conditions	Yield
With hydrogenchloride at 150℃; for 168h; pH=2; Autoclave;	83%

bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) + cadmium(II) oxide → Cd1.5(CH2CH2CO2)3Ge3O5

Conditions	Yield
With HNO3 In water High Pressure; mixt. of Ge-compound, CdO, HNO3 and H2O stirred for 2 h pH 3, heated at 150°C for 5 d; filtered; elem. anal.;	65%

neodymium(III) oxide + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → Nd8Ge12C36H48O48*30H2O

Conditions	Yield
at 140℃; for 170h; pH=3 - 7; Autoclave;	58%

2-pyrazylcarboxylic acid (98-97-5) + neodymium(III) oxide + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → {[Nd(2-pyrazinecarboxylato)2(H2O)][Nd8Ge12(μ3-O)24(-CH2CH2COO-)12(2-pyrazinecarboxylato)(H2O)12]}·3H2O

Conditions	Yield
Stage #1: neodymium(III) oxide; water; bis(2-carboxyethylgermanium(IV) sesquioxide) for 0.5h; Stage #2: 2-pyrazylcarboxylic acid With perchloric acid for 0.5h; pH=2; Stage #3: at 170℃; for 168h; Sealed tube;	57%

erbium(III) oxide + 1,10-Phenanthroline (66-71-7) + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → [Er8(1,10-phenanthroline)2Ge12(μ3-O)24(CH2CH2COO-)12(H2O)16]*2H2O

Conditions	Yield
With hydrogenchloride at 150℃; for 168h; pH=2; Autoclave;	57%

2-pyrazylcarboxylic acid (98-97-5) + neodymium(III) oxide + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → {([Nd(2-pyrazinecarboxylate)2(H2O)2]2[Nd8Ge12(CH2CH2COO)12(μ3-O)24(H2O)12])([Nd(2-pyrazinecarboxylate)2]2[Nd8Ge12(CH2CH2COO)12-(2-pyrazinecarboxylic acid)2(μ3-O)24(H2O)10])}*4OH*14H2O

Conditions	Yield
at 170℃; for 168.5h; pH=2 - 5; Autoclave;	56%

praseodymium oxide + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → Pr8Ge12C36H48O48*30H2O

Conditions	Yield
at 140℃; for 170h; pH=3 - 7; Autoclave;	55%

bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) + lead (II) hydroxide → Pb(CH2CH2CO2)2Ge2O3

Conditions	Yield
With HNO3 In water High Pressure; mixt. of Ge-compound, Pb(OH)2, HNO3 and H2O stirred for 2 h pH 3, heatedat 150°C for 5 d; filtered; elem. anal.;	53%

samarium(III) oxide + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → Sm8Ge12C36H48O48*30H2O

Conditions	Yield
at 140℃; for 170h; pH=3 - 7; Autoclave;	52%

2-Picolinic acid (98-98-6) + terbium(III, IV) oxide + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → {[Tb(2-picolinato)2(H2O)]3[Tb8Ge12(μ3-O)24(-CH2CH2COO-)12(H2O)4]}·(OH)3·10H2O

Conditions	Yield
Stage #1: terbium(III, IV) oxide; water; bis(2-carboxyethylgermanium(IV) sesquioxide) With 1,2-diaminopropan for 0.0833333h; Stage #2: 2-Picolinic acid With perchloric acid for 0.5h; pH=2; Stage #3: at 170℃; for 168h; Sealed tube;	52%

europium(III) oxide + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → Eu8Ge12C36H48O48*30H2O

Conditions	Yield
at 140℃; for 170h; pH=3 - 7; Autoclave;	45%

dysprosium((III) oxide + 1,10-Phenanthroline (66-71-7) + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → [Dy8(1,10-phenanthroline)2Ge12(μ3-O)24(CH2CH2COO-)12(H2O)16]*2H2O

Conditions	Yield
With hydrogenchloride at 150℃; for 168h; pH=2; Autoclave;	45%

2-pyrazylcarboxylic acid (98-97-5) + dysprosium((III) oxide + water (7732-18-5) + sodium formate dihydrate (51437-68-4, 100462-49-5, 104959-61-7) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → {[Dy(2-pyrazinecarboxylato)2(H2O)][Dy(2-pyrazinecarboxylato)2(H2O)2][Dy(2-pyrazinecarboxylato)3(H2O)][Dy8Ge12(μ3-O)24(-CH2CH2COO-)12(2-pyrazinecarboxylato)(HCOO)(H2O)6]}·5H2O

Conditions	Yield
Stage #1: 2-pyrazylcarboxylic acid; dysprosium((III) oxide; water; sodium formate dihydrate; bis(2-carboxyethylgermanium(IV) sesquioxide) for 0.5h; pH=3; Stage #2: at 170℃; for 168h; Sealed tube;	43%

gadolinium(III) oxide + 1,10-Phenanthroline (66-71-7) + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → [Gd8(1,10-phenanthroline)2Ge12(μ3-O)24(CH2CH2COO-)2(H2O)16]*2(1,10-phenanthroline)*16H2O

Conditions	Yield
With hydrogenchloride at 150℃; for 168h; pH=2; Autoclave;	43%

2-Picolinic acid (98-98-6) + Pyridine-2,6-dicarboxylic acid (499-83-2) + neodymium(III) oxide + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → {[Nd8Ge12(CH2CH2COO)12(μ3-O)24(H2O)10][Nd(2-picolinate)(2,6-pyridinedicarboxylate)(H2O)]2}*12H2O

Conditions	Yield
With perchloric acid at 170℃; for 168.5h; pH=2 - 5; Autoclave;	42%

2-pyrazylcarboxylic acid (98-97-5) + terbium(III) nitrate hexahydrate + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → {[TbGe(-CH2CH2COO-)(HO)2O(2-pyrazinecarboxylato)(H2O)]2[Tb8Ge12(μ3-O)24(-CH2CH2COO-)12(H2O)6]}·18H2O

Conditions	Yield
Stage #1: terbium(III) nitrate hexahydrate; water; bis(2-carboxyethylgermanium(IV) sesquioxide) With 1,2-diaminopropan for 0.5h; pH=6; Stage #2: 2-pyrazylcarboxylic acid for 0.5h; Stage #3: at 170℃; for 168h; Sealed tube;	41%

2-pyrazylcarboxylic acid (98-97-5) + Pyridine-2,6-dicarboxylic acid (499-83-2) + neodymium(III) oxide + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → {[Nd8Ge12(CH2CH2COO)12(μ3-O)24(H2O)10][Nd(2-pyrazinecarboxylate)(2,6-pyridinedicarboxylate)(H2O)]2}*12H2O

Conditions	Yield
With perchloric acid at 170℃; for 168.5h; pH=2 - 5; Autoclave;	40%

neodymium(III) oxide + malonic acid (141-82-2) + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → 2Nd2GeC3H6O5(4+)*Nd8Ge12C36H48O48*2CO3(2-)*4C2H3O2(1-)*18H2O

Conditions	Yield
at 140℃; for 170h; pH=2 - 7; Autoclave;	37%

2-Picolinic acid (98-98-6) + terbium(III, IV) oxide + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → [TbGe(CH2CH2COO)(HO)2O(H2O)(2-picolinate)]2[Tb8Ge12(CH2CH2COO)12-(μ3-O)24(H2O)8]*10H2O

Conditions	Yield
With perchloric acid at 170℃; for 168.5h; pH=2 - 5; Autoclave;	35%

gadolinium(III) oxide + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → Gd8Ge12C36H48O48*30H2O

Conditions	Yield
at 140℃; for 170h; pH=3 - 7; Autoclave;	32%

water (7732-18-5) + dysprosium acetate tetrahydrate (15280-55-4, 85077-87-8) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) + sodium carbonate (497-19-8) → {[Dy(CH3COO)(CO3)(H2O)]2[Dy8Ge12(μ3-O)24(-CH2CH2COO-)12(H2O)12]}·11H2O

Conditions	Yield
Stage #1: water; dysprosium acetate tetrahydrate; bis(2-carboxyethylgermanium(IV) sesquioxide); sodium carbonate for 0.5h; pH=6; Stage #2: at 170℃; for 144h; Sealed tube;	32%

holmium(III) oxide + 1,10-Phenanthroline (66-71-7) + water (7732-18-5) + bis(2-carboxyethylgermanium(IV) sesquioxide) (12758-40-6) → [Ho8(1,10-phenanthroline)2Ge12(μ3-O)24(CH2CH2COO-)12(H2O)14]*2(1,10-phenanthroline)*13H2O

Conditions	Yield
at 120℃; for 168h; pH=6; Autoclave;	32%

Related news

Research articleAntioxidative effect of Carboxyethylgermanium sesquioxide (cas 12758-40-6) (Ge-132) on IVM of porcine oocytes and subsequent embryonic development after parthenogenetic activation and IVF08/23/2019

Carboxyethylgermanium sesquioxide (Ge-132) is an organogermanium compound known to exert biological activities, such as antioxidant and anticancer effects. In this study, we investigated the effect of Ge-132 on the IVM of porcine oocytes via analysis of nuclear maturation, intracellular glutathi...detailed