1275874-85-5

Upstream product

• 58183-40-7 3-(p-tolyl)propionyl chloride 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 1505-50-6 3-(4-Methylphenyl)propanoic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 288310-94-1 1,1,1-trifluoro-4-(4-methylphenyl)butan-2-one 
• 53931-59-2 5-phenyl-1-penten-3-one 

Relevant academic research and scientific papers

Synthesis of 2-alkyl-2-boryl-substituted-tetrahydrofurans: Via copper(i)-catalysed borylative cyclization of aliphatic ketones

A new method was developed for synthesizing 2-alkyl-2-boryl-tetrahydrofuran derivatives from aliphatic ketones using a copper(i)/N-heterocyclic carbene complex catalyst. This reaction presumably proceeds through the nucleophilic addition of a borylcopper(i) intermediate to ketone, followed by intramolecular substitution of the resulting alkoxide for the halide leaving group. The new borylation products, 2-alkyl-2-boryl-tetrahydrofuran derivatives with a condensed structure around the C-B bond, cannot be synthesized by other methods.

A Weinreb amide approach to the synthesis of trifluoromethylketones

A novel route to access trifluoromethylketones (TFMKs) from Weinreb amides is reported. This represents the first documented case of the Ruppert-Prakash reagent (TMS-CF3) reacting in a constructive manner with an amide and enables synthesis of TMFKs without risk of over-trifluoromethylation.