1276034-29-7Relevant articles and documents
Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: Discovery of a quinazolinone chemotype
Beaulieu, Pierre L.,Coulombe, René,Duan, Jianmin,Fazal, Gulrez,Godbout, Cédrickx,Hucke, Oliver,Jakalian, Araz,Joly, Marc-André,Lepage, Olivier,Llinàs-Brunet, Montse,Naud, Julie,Poirier, Martin,Rioux, Nathalie,Thavonekham, Bounkham,Kukolj, George,Stammers, Timothy A.
, p. 4132 - 4140 (2013/07/25)
We describe the structure-based design of a novel lead chemotype that binds to thumb pocket 2 of HCV NS5B polymerase and inhibits cell-based gt1 subgenomic reporter replicons at sub-micromolar concentrations (EC50 200 nM). This new class of po